Dexpramipexole( R)-Pramipexole | KNS-760704 )

Catalog No. M10230 CAS No. 104632-28-2

A partial/full agonist of dopamine receptor with Ki of 3.9/2.2/0.5/5.1 nM for D2S/D2L/D3/D4, respeectively.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Dexpramipexole
Note

Research use only, not for human use.
Brief Description

A partial/full agonist of dopamine receptor with Ki of 3.9/2.2/0.5/5.1 nM for D2S/D2L/D3/D4, respeectively.
Description

A partial/full agonist of dopamine receptor with Ki of 3.9/2.2/0.5/5.1 nM for D2S/D2L/D3/D4, respeectively; also possesses low/insignificant affinity (500–10,000 nM) for the 5-HT1A, 5-HT1B, 5-HT1D, and α2-adrenergic receptors; used for treating Parkinson's disease (PD) and restless legs syndrome (RLS).Alzheimer's Disease Phase 2 Clinical.
In Vitro

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In Vivo

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Synonyms

R)-Pramipexole | KNS-760704
Pathway

GPCR/G Protein
Target

Dopamine Receptor
Recptor

Dopamine Receptor
Research Area

Neurological Disease
Indication

Alzheimer Disease

Chemical Information

CAS Number

104632-28-2
Formula Weight

211.3271
Molecular Formula

C10H17N3S
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

CCCNC1CCC2=C(C1)SC(=N2)N
Chemical Name

2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, (6R)-

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Alavian KN, et al. Brain Res. 2012 Mar 29;1446:1-11. 2. Cudkowicz M, et al. Nat Med. 2011 Nov 20;17(12):1652-6. 3. Bozik ME, et al. J Clin Pharmacol. 2011 Aug;51(8):1177-85.

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