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Talnetant

CAS No. 174636-32-9

Talnetant ( SB 223412 )

Catalog No. M20780 CAS No. 174636-32-9

Talnetant is a selective competitive brain-penetrant NK3 receptor antagonist with the ability to modulate mesolimbic and mesocortical dopaminergic neurotransmission.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Talnetant
  • Note
    Research use only not for human use.
  • Brief Description
    Talnetant is a selective competitive brain-penetrant NK3 receptor antagonist with the ability to modulate mesolimbic and mesocortical dopaminergic neurotransmission.
  • Description
    Talnetant is a selective competitive brain-penetrant NK3 receptor antagonist with the ability to modulate mesolimbic and mesocortical dopaminergic neurotransmission.
  • Synonyms
    SB 223412
  • Pathway
    GPCR/G Protein
  • Target
    Neurokinin Receptor
  • Recptor
    NK3
  • Research Area
    Metabolic Disease
  • Indication
    Chronic obstructive pulmonary disease; Cough; Irritable bowel syndrome

Chemical Information

  • CAS Number
    174636-32-9
  • Formula Weight
    382.45
  • Molecular Formula
    C25H22N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:100 mg/mL (261.47 mM)
  • SMILES
    CCC(NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1
  • Chemical Name
    3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Dawson L A Cato K J Scott C et al. In Vitro and In Vivo Characterization of the Non-peptide NK3 Receptor Antagonist SB-223412 (Talnetant): Potential Therapeutic Utility in the Treatment of Schizophrenia[J]. Neuropsychopharmacology 2008 33(7):1642-1652.
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