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Talarozole

CAS No. 201410-53-9

Talarozole ( R115866 )

Catalog No. M20727 CAS No. 201410-53-9

Talarozole is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM respectively.Talarozole for the treatment of acne psoriasis and other keratinization disorders.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 257 In Stock
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Biological Information

  • Product Name
    Talarozole
  • Note
    Research use only not for human use.
  • Brief Description
    Talarozole is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM respectively.Talarozole for the treatment of acne psoriasis and other keratinization disorders.
  • Description
    Talarozole is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM respectively.Talarozole for the treatment of acne psoriasis and other keratinization disorders.
  • Synonyms
    R115866
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    RAMBA;CYP
  • Research Area
    Infection
  • Indication
    Acne; Psoriasis

Chemical Information

  • CAS Number
    201410-53-9
  • Formula Weight
    377.51
  • Molecular Formula
    C21H23N5S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:36 mg/mL (95.36 mM)
  • SMILES
    CCC(CC)C(c1ccc(Nc2nc3ccccc3s2)cc1)n1cncn1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Elizabeth Pavez Loriè Chamcheu J C Vahlquist A et al. Both all-trans retinoic acid and cytochrome P450 (CYP26) inhibitors affect the expression of vitamin A metabolizing enzymes and retinoid biomarkers in organotypic epidermis[J]. Archives of Dermatological Research 2009 301(7):475-485.
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