
ULK1-IN-2
CAS No. 2497409-01-3
ULK1-IN-2( —— )
Catalog No. M35716 CAS No. 2497409-01-3
ULK1-IN-2 is a potent ULK1 inhibitor with potential anticancer activity, inducing apoptosis while blocking autophagy.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 78 | Get Quote |
![]() ![]() |
5MG | 116 | Get Quote |
![]() ![]() |
10MG | 188 | Get Quote |
![]() ![]() |
25MG | 419 | Get Quote |
![]() ![]() |
50MG | 635 | Get Quote |
![]() ![]() |
100MG | 1008 | Get Quote |
![]() ![]() |
500MG | 2007 | Get Quote |
![]() ![]() |
1G | Get Quote | Get Quote |
![]() ![]() |
Biological Information
-
Product NameULK1-IN-2
-
NoteResearch use only, not for human use.
-
Brief DescriptionULK1-IN-2 is a potent ULK1 inhibitor with potential anticancer activity, inducing apoptosis while blocking autophagy.
-
DescriptionULK1-IN-2 (compound 3s) is a potent ULK1 inhibitor. ULK1-IN-2 shows highest cytotoxic effect against cancer cell lines, with IC50 of 1.94 μM in A549. ULK1-IN-2 can induce apoptosis and simultaneously block autophagy, and can be used to study NSCLC (Non-small cell lung cancer).
-
In VitroULK1-IN-2 (compound 3s) (10 μM, 24 h) shows strong anti-proliferative activity against A549, U937, HL60, MDA-MB-468 and MCF-7.ULK1-IN-2 (0-8 μM, 24 h) blocks autophagy via inhibiting ULK1 in A549 cells.ULK1-IN-2 (0-8 μM, 24 h) induces apoptosis via the mitochondrial pathways in A549 cells in dose department manner.ULK1-IN-2 (0-8 μM, 24 h) inhibits ULK1 and p-ULK1ser317 expression in a concentration-dependent manner, remarkably decreases Bcl-2 expression, increases Bax and the active form of Caspase-3 expression.Cell Proliferation Assay Cell Line:Human cancer cell lines A549, U937, HL60, MDA-MB-468 and MCF-7 Concentration: 10 μM Incubation Time:24 h Result:Significantly improved anti-proliferative activity against A549, U937, HL60, MDA-MB-468 and MCF-7, with kinase inhibitory activity of 99.15% and IC50 values of 1.94, 12.92, 10.89, 16.83, and 19.60 μM, respectively.Cell Autophagy Assay Cell Line:A549 cells Concentration:0, 2, 4, 8 μM Incubation Time:24 h Result:Blocked autophagy of A549 cells via inhibiting ULK.Western Blot Analysis Cell Line:A549 cells Concentration:0, 2, 4, 8 μM Incubation Time:24 h Result:Inhibited expression of ULK1 and p-ULK1ser317 in a concentration-dependent manner. Increased the autophagy substrate P62, reduced LC3-I conversion to LC3-II, and decreased the levels of Beclin1. Remarkably decreased Bcl-2 expression, increased Bax and the active form of Caspase-3 expression.
-
In Vivo——
-
Synonyms——
-
PathwayAutophagy
-
TargetAutophagy
-
RecptorAutophagy | Apoptosis
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2497409-01-3
-
Formula Weight495.26
-
Molecular FormulaC19H16BrFN4O6
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 33.33 mg/mL (67.30 mM; Ultrasonic )
-
SMILESO(C)C1=C(OC)C=C(NC=2N=C(OC3=C(F)C=C(N(=O)=O)C=C3)C(Br)=CN2)C=C1OC
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Sun D, Yang Z, Zhen Y, et al. Discovery of 5-bromo-4-phenoxy-N-phenylpyrimidin-2-amine derivatives as novel ULK1 inhibitors that block autophagy and induce apoptosis in non-small cell lung cancer. Eur J Med Chem. 2020;208:112782.?
molnova catalog



related products
-
PHY34
PHY34 is a potent autophagy inhibitor with cytotoxic effects by inhibiting autophagy at a late stage (MDA-MB-435 IC50=23 nM, MDA-MB-231 IC50=5.2 nM); disrupts lysosomal function, significantly inhibits the growth of cancer cell lines in hollow fibers.
-
Imiquimod maleate
Imiquimod maleate (R 837 maleate) is a toll-like receptor 7 (TLR7) agonist and immune response modifier with antiviral and antitumor effects.
-
Sulfadoxine
Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract and malarial infections.