TX1-85-1 ( —— )

Catalog No. M23702 CAS No. 1603845-32-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

TX1-85-1
Note

Research use only, not for human use.
Brief Description

TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling.
Description

TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling. TX1-85-1 is an irreversible Her3 inhibitor (IC50: 23 nM). TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3.
Synonyms

——
Pathway

Angiogenesis
Target

EGFR
Recptor

ErbB3
Research Area

——
Indication

——

CAS Number

1603845-32-4
Formula Weight

580.7
Molecular Formula

C32H36N8O3
Purity

>98% (HPLC)
Solubility

DMSO:3.85 mg/mL (6.63 mM; Need ultrasonic)
SMILES

CC(N1CCN(C2CCC(N3N=C(C4=CC(NC(C=C)=O)=C(OC5=CC=CC=C5)C=C4)C6=C3N=CN=C6N)CC2)CC1)=O
Chemical Name

——

1.Xie T, et al. Pharmacological targeting of the pseudokinase Her3. Nat Chem Biol. 2014 Dec;10(12):1006-12.

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