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CHF5074
CAS No. 749269-83-8
CHF5074( CHF-5074 | CHF5074 | CHF 5074 | CSP-1103 )
Catalog No. M17588 CAS No. 749269-83-8
CHF5074, a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 45 | In Stock |
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| 5MG | 41 | In Stock |
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| 10MG | 65 | In Stock |
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| 25MG | 130 | In Stock |
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| 50MG | 203 | In Stock |
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| 100MG | 305 | In Stock |
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| 200MG | 440 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCHF5074
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NoteResearch use only, not for human use.
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Brief DescriptionCHF5074, a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).
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DescriptionCHF-5074, also known as CSP-1103, is a γ-secretase modulator. CHF-5074 reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM respectively. CHF5074 reduces brain beta-Amyloid pathology in a transgenic mouse model of Alzheimer's Disease without causing peripheral toxicity. CHF5074 is a non-steroidal anti-inflammatory derivative holding disease-modifying potential for the treatment of Alzheimer's disease.
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In Vitro——
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In VivoAnimal Model:Male and female Tg2576 transgenic mice expressing Swedish mutated form of human APP (APPswe)Dosage:375 ppm Administration:Oral administration; 375 ppm in the diet for 17 weeks Result:Reduced total brain Aβ42 and Aβ40 levels, and brain plaque burden in aged Tg2576 mice. Caused no COX-mediated toxic effects in the gastrointestinal tract and Notch-mediated cell differentiation abnormalities in the ileum.
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SynonymsCHF-5074 | CHF5074 | CHF 5074 | CSP-1103
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PathwayAngiogenesis
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TargetEGFR
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RecptorBeta Amyloid| γ secretase
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number749269-83-8
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Formula Weight325.16
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Molecular FormulaC16H11Cl2FO2
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 37 mg/mL; 113.79 mM
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SMILESClc1cc(c2c(F)cc(C3(CC3)C(=O)O)cc2)ccc1Cl
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Chemical Name1-[4-(3,4-dichlorophenyl)-3-fluorophenyl]cyclopropane-1-carboxylic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Imbimbo BP, et al. J Pharmacol Exp Ther. 2007 Dec;323(3):822-30. 2. Ronsisvalle N, et al. Curr Alzheimer Res. 2014;11(7):714-24.
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