Cart
sales@molnova.com
Monastrol
CAS No. 254753-54-3
Monastrol( Monastrol )
Catalog No. M19323 CAS No. 254753-54-3
Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameMonastrol
-
NoteResearch use only, not for human use.
-
Brief DescriptionMonastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.
-
DescriptionMonastrol is a kinesin Eg5 inhibitor. Induction of apoptosis by monastrol is independent of the spindle checkpoint. Monastrol binds to the KSP-ADP complex, forming a KSP-ADP- monastrol ternary complex, which cannot bind to microtubules productively and cannot undergo further ATP-driven conformational changes.
-
In Vitro——
-
In Vivo——
-
SynonymsMonastrol
-
PathwayAngiogenesis
-
TargetEGFR
-
RecptorEg5
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number254753-54-3
-
Formula Weight292.35
-
Molecular FormulaC14H16N2O3S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCCOC(=O)C1=C(NC(=S)NC1C2=CC(=CC=C2)O)C
-
Chemical Nameethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Cochran JC, et al. Monastrol inhibition of the mitotic kinesin Eg5. J BiolChem. 2005 Apr 1;280(13):12658-67.
molnova catalog
related products
-
BLU-945
BLU-945 is a reversible, potent, highly selective, and orally available epidermal growth factor receptor tyrosine kinase inhibitor (TKIs).
-
LY 456236 hydrochlor...
LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM. LY456236 has selective, non-competitive and oral activity, and can inhibit the hydrolysis of inositol phosphate with IC50 of 0.145 μM.
-
VUF 10166
VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.
