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Monastrol
CAS No. 254753-54-3
Monastrol( Monastrol )
Catalog No. M19323 CAS No. 254753-54-3
Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 5MG | 873 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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Biological Information
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Product NameMonastrol
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NoteResearch use only, not for human use.
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Brief DescriptionMonastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.
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DescriptionMonastrol is a kinesin Eg5 inhibitor. Induction of apoptosis by monastrol is independent of the spindle checkpoint. Monastrol binds to the KSP-ADP complex, forming a KSP-ADP- monastrol ternary complex, which cannot bind to microtubules productively and cannot undergo further ATP-driven conformational changes.
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In Vitro——
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In Vivo——
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SynonymsMonastrol
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PathwayAngiogenesis
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TargetEGFR
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RecptorEg5
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Research Area——
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Indication——
Chemical Information
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CAS Number254753-54-3
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Formula Weight292.35
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Molecular FormulaC14H16N2O3S
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Purity>98% (HPLC)
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Solubility——
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SMILESCCOC(=O)C1=C(NC(=S)NC1C2=CC(=CC=C2)O)C
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Chemical Nameethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Cochran JC, et al. Monastrol inhibition of the mitotic kinesin Eg5. J BiolChem. 2005 Apr 1;280(13):12658-67.
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