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TRX-0237

CAS No. 613-11-6

TRX-0237( Hydromethylthionine | Methylene blue )

Catalog No. M15309 CAS No. 613-11-6

TRX-0237 Methylate (Hydromethylthionine, Methylene blue) is a Tau aggregation inhibitor (TAI) with Ki of 0.12 uM for intracellular TAI activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TRX-0237
  • Note
    Research use only, not for human use.
  • Brief Description
    TRX-0237 Methylate (Hydromethylthionine, Methylene blue) is a Tau aggregation inhibitor (TAI) with Ki of 0.12 uM for intracellular TAI activity.
  • Description
    TRX-0237 Methylate (Hydromethylthionine, Methylene blue) is a Tau aggregation inhibitor (TAI) with Ki of 0.12 uM for intracellular TAI activity; disrupts paired helical filaments (PHFs) isolated from AD brain tissues at 0.16 uM, delays cellular senescence and enhances key mitochondrial biochemical pathways; demonstrates activities in clinical trials in Alzheimer's disease (AD) with drugs targeting β-amyloid accumulation in the brain.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Hydromethylthionine | Methylene blue
  • Pathway
    Others
  • Target
    Amyloids
  • Recptor
    Amyloids
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    613-11-6
  • Formula Weight
    379.493
  • Molecular Formula
    C16H19N3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CN(C)C1=CC2=C(C=C1)NC3=C(S2)C=C(C=C3)N(C)C
  • Chemical Name
    3,7-bis(dimethylamino)phenothiazin-5-ium

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Harrington CR, et al. J Biol Chem. 2015 Apr 24;290(17):10862-75. 2. Atamna H, et al. FASEB J. 2008 Mar;22(3):703-12. 3. Seripa D, et al. Expert Rev Neurother. 2016;16(3):259-77. 4. Wilcock GK, et al. J Alzheimers Dis. 2018;61(1):435-457.
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