BNC-1

CAS No. 96335-59-0

BNC-1( BNC-1 | BNC 1 | BNC1 )

Catalog No. M16864 CAS No. 96335-59-0

BNC-1 is a small molecule modulator of Amyloid pathology by promoting phosphorylation and activation of Elk-1.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
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Biological Information

  • Product Name
    BNC-1
  • Note
    Research use only, not for human use.
  • Brief Description
    BNC-1 is a small molecule modulator of Amyloid pathology by promoting phosphorylation and activation of Elk-1.
  • Description
    BNC-1 is a small molecule modulator of Amyloid pathology by promoting phosphorylation and activation of Elk-1, a transcriptional repressor of presenilin-1 but not presenilin-2; increases levels of synaptophysin and synapsin, markers of synaptic integrity, but does not adversely impact presenilin-2 or processing of Notch-1, significantly decreases amyloid burden and improves markers of synaptic integrity in a well-established mouse model of amyloid deposition.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    BNC-1 | BNC 1 | BNC1
  • Pathway
    Others
  • Target
    Amyloids
  • Recptor
    Amyloids
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    96335-59-0
  • Formula Weight
    282.299
  • Molecular Formula
    C16H14N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C(C(C)=NC(C)=C12)=C2C3=CC=CC=C3NC1=O)OC
  • Chemical Name
    Methyl 2,4-dimethyl-5-oxo-5,6-dihydrobenzo[c][2,7]naphthyridine-1-carboxylate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lovell MA, et al. J Alzheimers Dis. 2016 May 4;53(1):273-87.
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