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TR-100

CAS No. 1128165-86-5

TR-100( TR100 | TR 100 )

Catalog No. M10450 CAS No. 1128165-86-5

TR-100 (TR100) is a specific anti-tropomyosin compound that disrupts the actin cytoskeleton via targeting of Tpm3.1-containing actin filaments.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TR-100
  • Note
    Research use only, not for human use.
  • Brief Description
    TR-100 (TR100) is a specific anti-tropomyosin compound that disrupts the actin cytoskeleton via targeting of Tpm3.1-containing actin filaments.
  • Description
    TR-100 (TR100) is a specific anti-tropomyosin compound that disrupts the actin cytoskeleton via targeting of Tpm3.1-containing actin filaments; perturbs Tpm3.1-regulated actin filament depolymerisation from the barbed end without affecting the capacity of Tpm3.1 to regulate barbed end actin elongation or bind F-actin; TR-100 (TR100) is effective in vitro and in vivo in reducing tumor cell growth in neuroblastoma and melanoma models.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    TR100 | TR 100
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Microtubule/Tubulin
  • Recptor
    Microtubule/Tubulin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1128165-86-5
  • Formula Weight
    422.617
  • Molecular Formula
    C26H38N4O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(NCCCCCCCC)/C(C#N)=C/C1=C(C)N(CCCN(C)C)C2=C1C=CC=C2
  • Chemical Name
    2-Cyano-3-[1-[3-(dimethylamino)propyl]-2-methyl-1H-indol-3-yl]-N-octyl-2-propenamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Stehn JR, et al. Cancer Res. 2013 Aug 15;73(16):5169-82. 2. Bonello TT, et al. Sci Rep. 2016 Jan 25;6:19816. 3. Currier MA, et al. Mol Cancer Ther. 2017 Aug;16(8):1555-1565. 4. Kee AJ, et al. Sci Rep. 2018 Mar 15;8(1):4604.
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