Cart
sales@molnova.com
Home - Products - Cytoskeleton/Cell Adhesion Molecules - Microtubule/Tubulin - Mc-MMAE

Mc-MMAE

CAS No. 863971-24-8

Mc-MMAE( Maleimidocaproyl-monomethylauristatin E )

Catalog No. M26983 CAS No. 863971-24-8

Mc-MMAE is a drug-linker conjugate for ADC. Mc-MMAE is a maleimidocaproyl-conjugated monomethyl auristatin E, which is a potent tubulin inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 394 Get Quote
10MG 617 Get Quote
25MG 963 Get Quote
50MG 1305 Get Quote
100MG 1755 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Mc-MMAE
  • Note
    Research use only, not for human use.
  • Brief Description
    Mc-MMAE is a drug-linker conjugate for ADC. Mc-MMAE is a maleimidocaproyl-conjugated monomethyl auristatin E, which is a potent tubulin inhibitor.
  • Description
    Mc-MMAE is a drug-linker conjugate for ADC. Mc-MMAE is a maleimidocaproyl-conjugated monomethyl auristatin E, which is a potent tubulin inhibitor.(In Vitro):The synthesis of Mc-MMAE requires the addition of maleimidohexanoic acid in a solution of monomethyl auristatin E in dichloromethane, followed by addition of diethyl cyanophosphonate and diisopropylethylamine .
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Maleimidocaproyl-monomethylauristatin E
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Microtubule/Tubulin
  • Recptor
    IKKα
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    863971-24-8
  • Formula Weight
    911.195
  • Molecular Formula
    C49H78N6O10
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 180 mg/mL (197.55 mM)
  • SMILES
    CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)CCCCCN1C(=O)C=CC1=O)C(C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Pletz N, et al. Doxorubicin-induced activation of NF-κB in melanoma cells is abrogated by inhibition of IKKβ, but not by a novel IKKα inhibitor. Exp Dermatol. 2012 Apr;21(4):301-4.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Isosorbide Mononitra...

    Isosorbide mononitrate is a Nitrate Vasodilator, dilating the blood vessels so as to reduce the blood pressure.

  • SSE15206

    SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells.

  • Tubulin inhibitor 24

    Tubulin inhibitor 24 is a potent inhibitor that can inhibit tubulin polymerization.

Sign In Join Free