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Home - Products - Wnt/Notch/Hedgehog - Wnt/beta/catenin - TNIK-IN-5

TNIK-IN-5

CAS No. 2754265-66-0

TNIK-IN-5( —— )

Catalog No. M28917 CAS No. 2754265-66-0

TNIK-IN-5 is an inhibitor of TNIK and can be used in studies about the treatment of anti-tumor and anti-inflammatory diseases.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TNIK-IN-5
  • Note
    Research use only, not for human use.
  • Brief Description
    TNIK-IN-5 is an inhibitor of TNIK and can be used in studies about the treatment of anti-tumor and anti-inflammatory diseases.
  • Description
    TNIK-IN-5 is an inhibitor of TNIK and can be used in studies about the treatment of anti-tumor and anti-inflammatory diseases.
  • In Vitro
    TNIK-IN-5 (compound 8g) (1.25-5 μM; 48 hours) significantly inhibits the cell proliferation of HCT116 in a dose-dependent manner.TNIK-IN-5 (1 μM; 24, 48 hours) strongly prevents HCT116 cells migration.TNIK-IN-5 (10-40 μM; 48 hours) concentration-dependently inhibits the protein levels of β-catenin and TCF-4 in the nucleus, and significantly decreases the expression of Wnt target gene products, including Axin2 and c-Myc.Cell Proliferation Assay Cell Line:HCT116?cells Concentration:1.25 μM, 2.5 μM, 5 μMIncubation Time:48 hours Result:Significantly inhibited the cell proliferation in a dose-dependent manner.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Wnt/Notch/Hedgehog
  • Target
    Wnt/beta/catenin
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2754265-66-0
  • Formula Weight
    371.39
  • Molecular Formula
    C22H17N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1OC=2C=C(C=CC2N1CC=3C=CC=C(OC)C3)C4=CN=C5NC=CC5=C4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Tabefam M, et al. Antiprotozoal Diterpenes from Perovskia abrotanoides. Planta Med. 2018 Aug;84(12-13):913-919.
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