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Miclxin

CAS No. 2494198-61-5

Miclxin( —— )

Catalog No. M36523 CAS No. 2494198-61-5

Miclxin (DS37262926) is a novel MIC60 inhibitor that induces apoptosis through mitochondrial stress in mutant tumor cells via β-catenin.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 146 Get Quote
5MG 227 Get Quote
10MG 320 Get Quote
25MG 523 Get Quote
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Biological Information

  • Product Name
    Miclxin
  • Note
    Research use only, not for human use.
  • Brief Description
    Miclxin (DS37262926) is a novel MIC60 inhibitor that induces apoptosis through mitochondrial stress in mutant tumor cells via β-catenin.
  • Description
    Miclxin (DS37262926) is a potent inhibitor of mutant β-catenin, involving in Wnt signaling pathway. Miclxin induces β-catenin-dependent apoptosis, leads to severe mitochondrial damage with the loss of mitochondrial membrane. Miclxin kills tumor via targeting to MIC60, a major components of the mitochondrial contact site and cristae organizing system (MICOS) complex.
  • In Vitro
    Cell Viability Assay Cell Line:HCT116 (CTNNB1 +/–) and (CTNNB1 △45/–)Concentration:0, 5, 8, 10, 12, and 15 μM Incubation Time:48 hours Result:Inhibited cell growth with inhibition rate of 100% at 15 μM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Wnt/Notch/Hedgehog
  • Target
    Wnt/beta/catenin
  • Recptor
    Wnt/beta-catenin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2494198-61-5
  • Formula Weight
    441.52
  • Molecular Formula
    C26H27N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 10 mg/mL (22.65 mM; Ultrasonic (<80°C)
  • SMILES
    N(CC1=CC(OC)=CC=C1)C=2C3=C(N=C(N2)N4CC(CC4)C=5C=CC=NC5)C=C(OC)C=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ikeda H, et al. Miclxin, a Novel MIC60 Inhibitor, Induces Apoptosis via Mitochondrial Stress in β-Catenin Mutant Tumor Cells. ACS Chem Biol. 2020 Aug 21;15(8):2195-2204. ?
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