Roquinimex

Research use only, not for human use.

Roquinimex (Linomide) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces the secretion of TNF alpha.

Roquinimex, also known as LS 2616 and FCF89 (brande name: Linomide), is a quinoline-3-carboxamide with potential antineoplastic activity. Roquinimex inhibits endothelial cell proliferation, migration, and basement membrane invasion; reduces the secretion of the angiogenic factor tumor necrosis factor alpha by tumor-associated macrophages (TAMs); and inhibits angiogenesis. This agent is also an immune modulator that appears to alter cytokine profiles and enhance the activity of T cells, natural killer cells, and macrophages.

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FCF89 | FCF89 | LS 2616 | Linomide. US brand name: Linomide

Wnt/Notch/Hedgehog

Wnt/beta/catenin

Others

Inflammation/Immunology

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84088-42-6

308.34

C18H16N2O3

>98% (HPLC)

DMSO : ≥ 83.3 mg/mL; 270.17 mM

CN(c1ccccc1)C(=O)C3=C(O)c2ccccc2N(C)C3=O

4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide

(-20℃)

With Ice Pack

≥ 2 years