TMP-269

Research use only, not for human use.

A potent and selective class IIa HDAC inhibitor.

A potent and selective class IIa HDAC inhibitor with IC50s of 126/80/36/19 nM for HDAC4/5/7/9; less potent or no inhibition for others HDAC isoforms (>2 uM); prevents cell cycle progression, DNA synthesis, and proliferation induced in response to G protein-coupled receptor/PKD1 activation in IEC-18 cells.

TMP 269;TMP269

Cell Cycle/DNA Damage

HDAC

HDAC4;HDAC5;HDAC7;HDAC9

Cancer

——

1314890-29-3

514.52

C25H21F3N4O3S

>98% (HPLC)

DMSO: ≥ 41 mg/mL

O=C(NCC1(C2=NC(C3=CC=CC=C3)=CS2)CCOCC1)C4=CC=CC(C5=NOC(C(F)(F)F)=N5)=C4

Benzamide, N-[[tetrahydro-4-(4-phenyl-2-thiazolyl)-2H-pyran-4-yl]methyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]-

(-20℃)

With Ice Pack

≥ 2 years