TMP-269

CAS No. 1314890-29-3

TMP-269 ( TMP 269;TMP269 )

Catalog No. M11270 CAS No. 1314890-29-3

A potent and selective class IIa HDAC inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 59 In Stock
5MG 87 In Stock
10MG 148 In Stock
25MG 247 In Stock
50MG 445 In Stock
100MG 537 In Stock
200MG 773 In Stock
500MG 1161 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    TMP-269
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective class IIa HDAC inhibitor.
  • Description
    A potent and selective class IIa HDAC inhibitor with IC50s of 126/80/36/19 nM for HDAC4/5/7/9; less potent or no inhibition for others HDAC isoforms (>2 uM); prevents cell cycle progression, DNA synthesis, and proliferation induced in response to G protein-coupled receptor/PKD1 activation in IEC-18 cells.
  • Synonyms
    TMP 269;TMP269
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC4;HDAC5;HDAC7;HDAC9
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1314890-29-3
  • Formula Weight
    514.52
  • Molecular Formula
    C25H21F3N4O3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 41 mg/mL
  • SMILES
    O=C(NCC1(C2=NC(C3=CC=CC=C3)=CS2)CCOCC1)C4=CC=CC(C5=NOC(C(F)(F)F)=N5)=C4
  • Chemical Name
    Benzamide, N-[[tetrahydro-4-(4-phenyl-2-thiazolyl)-2H-pyran-4-yl]methyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lobera M, et al. Nat Chem Biol. 2013 May;9(5):319-25.
2. Sinnett-Smith J, et al. Am J Physiol Cell Physiol. 2014 May 15;306(10):C961-71.
3. Kikuchi S, et al. Leukemia. 2015 Sep;29(9):1918-27.
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