ACY-957 ( ACY957 )

Catalog No. M12316 CAS No. 1609389-52-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ACY-957
Note

Research use only, not for human use.
Brief Description

ACY-957 (ACY957) is a potent, selective inhibitor of HDAC1 and HDAC2 with IC50 of 7 and 18 nM.
Description

ACY-957 (ACY957) is a potent, selective inhibitor of HDAC1 and HDAC2 with IC50 of 7 and 18 nM, shows limited activity against HDAC3 (IC50=1,300 nM) and no activity against HDAC4/5/6/7/8/9 (IC50>20 nM); elicits dependent induction of γ-globin mRNA (HBG) and HbF protein in a variety of primary erythroid progenitor cell culture system, increases GATA2 expression, elevates histone acetylation at well-known GATA2 autoregulatory regions.
Synonyms

ACY957
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC
Research Area

Other Indications
Indication

——

CAS Number

1609389-52-7
Formula Weight

429.54
Molecular Formula

C24H23N5OS
Purity

>98% (HPLC)
Solubility

DMSO : 83.33 mg/mL. 194.00 mM
SMILES

O=C(C1=CC=C2N=C(N3CCNCC3)C=CC2=C1)NC4=CC(C5=CC=CS5)=CC=C4N
Chemical Name

N-[2-Amino-5-(2-thienyl)phenyl]-2-(1-piperazinyl)-6-quinolinecarboxamide

1. Shearstone JR, et al. PLoS One. 2016 Apr 13;11(4):e0153767.

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