TM-25659
CAS No. 260553-97-7
TM-25659 ( —— )
Catalog No. M26484 CAS No. 260553-97-7
TM-25659 is a modulator of transcriptional co-activator with PDZ-binding motif (TAZ), with anti-osteoporotic and anti-obesity activities.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 71 | In Stock |
|
5MG | 115 | In Stock |
|
10MG | 177 | In Stock |
|
25MG | 425 | In Stock |
|
50MG | 624 | In Stock |
|
100MG | Get Quote | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTM-25659
-
NoteResearch use only, not for human use.
-
Brief DescriptionTM-25659 is a modulator of transcriptional co-activator with PDZ-binding motif (TAZ), with anti-osteoporotic and anti-obesity activities.
-
DescriptionTM-25659 is a modulator of transcriptional co-activator with PDZ-binding motif (TAZ), with anti-osteoporotic and anti-obesity activities.(In Vitro):Treatment with TM-25659 (2, 10, 20, 100 μM) dose-dependently enhances nuclear TAZ localization and attenuates PPARγ-mediated adipocyte differentiation by facilitating PPARγ suppression activity of TAZ. Osteogenic gene expression is enhanced by TM-25659 (2, 10, 50 μM) and thereby osteoblast differentiation is increased.(In Vivo):In vivo, TM-25659 (50 mg/kg, i.p., every other day for 2 weeks) suppresses bone loss and decreases weight gain in an obesity model. The plasma concentration of TM-25659 declines with an approximate t1/2 of 7 or 10 h following i.v or p.o. administration respectively. The systemic clearance (CL) is 0.21 L/(h×kg) and the volume of distribution at steady-state (1.91 L/(h×kg)) is larger than the volume of total body fluids.
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorHCV
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number260553-97-7
-
Formula Weight500.6
-
Molecular FormulaC30H28N8
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCCCCc1nc2cc(-c3cccnc3)c(C)nc2n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Jean-Pierre Sommadossi, et al. Beta-D-2'-DEOXY-2'-alpha-FLUORO-2'-beta-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR HCV TREATMENT. US20160257706A1
molnova catalog
related products
-
Erythritol
Erythritol is a sugar alcohol used as low-calorie sweetener.
-
Isonormangostin
Isonormangostin is a natural product of Garcinia, Clusiaceae. Isonormangostin can be used as a reference standard.
-
Methyl 4-Hydroxyphen...
Methyl 4-Hydroxyphenylacetate has potent inhibitory activity against tobacco mosaic virus (TMV).