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TH-287
CAS No. 1609960-30-6
TH-287( TH287 )
Catalog No. M12321 CAS No. 1609960-30-6
A potent and selective inhibitor of MTH1 protein with IC50 of 0.8 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 37 | In Stock |
|
| 5MG | 59 | In Stock |
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| 10MG | 87 | In Stock |
|
| 25MG | 178 | In Stock |
|
| 50MG | 347 | In Stock |
|
| 100MG | 516 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTH-287
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective inhibitor of MTH1 protein with IC50 of 0.8 nM.
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DescriptionA potent and selective inhibitor of MTH1 protein with IC50 of 0.8 nM; shows no relevant inhibition for MTH2,NUDT5, NUDT12,NUDT14,NUDT16 and other proteinswith known nucleoside triphosphate pyrophosphatase activity; causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.
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In VitroTH287 (1-10 μM; 24 h) selectively and effectively kills U2OS and other cancer cell lines, but is considerably less toxic to several primary or immortalized cells.
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In VivoTH287 (5 mg/kg; i.p.) exhibits Cmax of 0.82 μM and tmax of 0.5 h in mice.
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SynonymsTH287
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorMTH1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1609960-30-6
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Formula Weight269.1299
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Molecular FormulaC11H10Cl2N4
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 2.6 mg/mL
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SMILESNC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC)=N1
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Chemical Name2,4-Pyrimidinediamine, 6-(2,3-dichlorophenyl)-N4-methyl-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gad H, et al. Nature. 2014 Apr 10;508(7495):215-21.
2. Wang M, et al. Sci Rep. 2017 Jan 11;7:40557.
3. Kawamura T, et al. Sci Rep. 2016 May 23;6:26521.
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