Pyridostatin

Research use only, not for human use.

Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay.

Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2.

Pyridostatin (RR82) (10 μM; 48 hours) induces cell cycle arrest. Pyridostatin is a very selective G-quadruplex DNA-binding small molecule designed to form a complex with and stabilize G-quadruplex structure. Pyridostatin causes neurite retraction, synaptic loss, and dose-dependent neuronal death. In cultured primary neurons, Pyridostatin induces the formation of DNA DSBs. Remarkably, Pyridostatin (1-5 μM, overnight) down regulates the BRCA1 protein, a protein that guards and repairs the neuronal genome, at the transcriptional level. They are for reference only.Pyridostatin:Cell Viability Assay Cell Line:Over 60 different cancer cell lines Concentration:10 μM Incubation Time:48 hours Result:Predominantly accumulated in the G2 phase of the cell cycle over 60 different cancer cell lines.

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Cell Cycle/DNA Damage

DNA/RNA Synthesis

G-quadruplexe

Cancer

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1085412-37-8

596.64

C31H32N8O5

>98% (HPLC)

Ethanol: 30 mg/mL 30; Water: 100 mg/mL 100; DMSO: 100 mg/mL 100

NCCOC1=CC(=NC(=C1)C(=O)NC1=NC2=CC=CC=C2C(OCCN)=C1)C(=O)NC1=NC2=CC=CC=C2C(OCCN)=C1

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(-20℃)

With Ice Pack

≥ 2 years