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Home - Products - Cell Cycle/DNA Damage - DNA/RNA Synthesis - GSK-3484862

GSK-3484862

CAS No. 2170136-65-7

GSK-3484862( —— )

Catalog No. M26234 CAS No. 2170136-65-7

Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity. Gsk-3484862 mediates the global demethylation of mouse embryonic stem cells.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    GSK-3484862
  • Note
    Research use only, not for human use.
  • Brief Description
    Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity. Gsk-3484862 mediates the global demethylation of mouse embryonic stem cells.
  • Description
    Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity. Gsk-3484862 mediates the global demethylation of mouse embryonic stem cells.
  • In Vitro
    GSK-3484862 (0-10 μM, 6 or 14 days) induces dramatic DNA methylation loss.GSK-3484862 (0-10 μM, 4 days) results in a modest reduction in DNMT1 protein level. Cell Viability Assay Cell Line:Murine embryonic stem cells (mESC, wild-type (WT) or Dnmt1/3a/3b triple knockout (TKO))Concentration:2 μM and 10 μM Incubation Time:6 or 14 days Result:Induced dramatic DNA methylation loss, with global CpG methylation levels falling from near 70% in WT mESC to less than 18% after 6 days.Western Blot Analysis Cell Line:Murine embryonic stem cells (mESC, wild-type (WT) or Dnmt1/3a/3b triple knockout (TKO))Concentration:2 μM and 10 μM Incubation Time:4 days Result:Resulted in a modest reduction in DNMT1 protein level.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2170136-65-7
  • Formula Weight
    365.46
  • Molecular Formula
    C19H19N5OS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 20.83 mg/mL (57.00 mM)
  • SMILES
    CCc1c(C#N)c(S[C@@H](C(N)=O)c2ccccc2)nc(N(C)C)c1C#N
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Pereira V, Le?a JM, Gaspar JM, Pereira AC, Marques JC. Rapid Determination of Sotolon in Fortified Wines Using a Miniaturized Liquid-Liquid Extraction Followed by LC-MS/MS Analysis. J Anal Methods Chem. 2018 Dec 16;2018:4393040.
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