TC-I2000 ( —— )

Catalog No. M21933 CAS No. 1159996-20-9

TC-I2000 is an TRPM8 channel blocker. Inhibits?icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells with IC50?of 53 nM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

TC-I2000
Note

Research use only, not for human use.
Brief Description

TC-I2000 is an TRPM8 channel blocker. Inhibits?icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells with IC50?of 53 nM.
Description

TC-I2000 is an TRPM8 channel blocker. Inhibits?icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells with IC50?of 53 nM.
Synonyms

——
Pathway

Membrane Transporter/Ion Channel
Target

TRP/TRPV Channel
Recptor

TRPM8
Research Area

——
Indication

——

Chemical Information

CAS Number

1159996-20-9
Formula Weight

414.4
Molecular Formula

C23H18F4N2O?
Purity

>98% (HPLC)
Solubility

——
SMILES

Fc1ccc(NC(=O)N2CCc3ccccc3C2c2ccc(cc2)C(F)(F)F)cc1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Tamayo N A , Bo Y , Gore V , et al. Fused Piperidines as a Novel Class of Potent and Orally Available Transient Receptor Potential Melastatin Type 8 (TRPM8) Antagonists[J]. Journal of Medicinal Chemistry, 2012, 55(4):1593-1611.

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