TBBD ( Ellagic acid )

Catalog No. M14590 CAS No. 476-66-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

TBBD
Note

Research use only, not for human use.
Brief Description

TBBD is a specific inhibitor of coactivator-associated arginine methyltransferase 1 (CARM1; PRMT4) that selectively inhibits methylation at arginine 17 of histone H3 (H3R17).
Description

TBBD is a specific inhibitor of coactivator-associated arginine methyltransferase 1 (CARM1; PRMT4) that selectively inhibits methylation at arginine 17 of histone H3 (H3R17); shows no significant effect on the HMTase activity of G9a, as well as on the HAT activity of p300/CBP-associated factor.
Synonyms

Ellagic acid
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

Carbonicanhydrase;CK2;PKA;PKC;Smoothened;Syk
Research Area

Cancer
Indication

——

CAS Number

476-66-4
Formula Weight

302.19
Molecular Formula

C14H6O8
Purity

>98% (HPLC)
Solubility

Ethanol: 0.2 mg/mL (0.65 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

O=C1C2=CC(O)=C(O)C(O3)=C2C4=C(C3=O)C=C(O)C(O)=C4O1
Chemical Name

2,3,7,8-tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione

1. Selvi BR, et al. J Biol Chem. 2010 Mar 5;285(10):7143-52.
2. Hatanaka Y, et al. Cell Rep. 2017 Sep 19;20(12):2756-2765.

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