MM-102 ( MM102;MM 102 )

Catalog No. M11741 CAS No. 1417329-24-8

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Datasheet

HNMR

HPLC

MSDS

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Product Name

MM-102
Note

Research use only, not for human use.
Brief Description

A high-affinity, small-molecule peptidomimetic inhibitor of MLL1/WDR5 protein-protein interaction with Ki of 2.4 nM.
Description

A high-affinity, small-molecule peptidomimetic inhibitor of MLL1/WDR5 protein-protein interaction with Ki of 2.4 nM; effectively decreases the expression of HoxA9 and Meis-1; specifically inhibits cell growth and induces apoptosis in leukemia cells harboring MLL1 fusion proteins.
Synonyms

MM102;MM 102
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

MLL1
Research Area

Cancer
Indication

——

CAS Number

1417329-24-8
Formula Weight

669.80
Molecular Formula

C35H49F2N7O4
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=C(C1(NC([C@@H](NC(C(NC(C(C)C)=O)(CC)CC)=O)CCC/N=C(N)/N)=O)CCCC1)NC(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3
Chemical Name

Cyclopentanecarboxamide, 1-[[(2S)-5-[(aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]-

1. Karatas H, et al. J Am Chem Soc. 2013 Jan 16;135(2):669-82.

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