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TAK-779

CAS No. 229005-80-5

TAK-779 ( TAK779;TAK 799;Takeda 779 )

Catalog No. M13635 CAS No. 229005-80-5

TAK-779 is a potent, specific, nonpeptide CCR5 antagonist with Kd of 0.45 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TAK-779
  • Note
    Research use only, not for human use.
  • Brief Description
    TAK-779 is a potent, specific, nonpeptide CCR5 antagonist with Kd of 0.45 nM.
  • Description
    TAK-779 is a potent, specific, nonpeptide CCR5 antagonist with Kd of 0.45 nM, antagonizes CCR2b to a lesser extent (27 nM) but does not affect CCR1, CCR3, or CCR4; also blocks the binding of macrophage inflammatory protein 1α and macrophage inflammatory protein 1β to the cells with an IC50 of 1.0 nM; TAK-779 displays highly potent and selective inhibition of the replication of macrophage (M)-tropic HIV-1 (Ba-L strain) in both MAGI-CCR5 cells and PBMCs with EC50 of 1.2 and 3.7 nM, respectively.HIV Infection Discontinued
  • Synonyms
    TAK779;TAK 799;Takeda 779
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV
  • Research Area
    Infection
  • Indication
    HIV Infection

Chemical Information

  • CAS Number
    229005-80-5
  • Formula Weight
    531.10
  • Molecular Formula
    C33H39ClN2O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 27 mg/mL
  • SMILES
    CC1=CC=C(C=C1)C2=CC3=C(CCCC(=C3)C(=O)NC4=CC=C(C=C4)C[N+](C)(C)C5CCOCC5)C=C2.[Cl-]
  • Chemical Name
    2H-Pyran-4-aminium, N-[[4-[[[6,7-dihydro-2-(4-methylphenyl)-5H-benzocyclohepten-8-yl]carbonyl]amino]phenyl]methyl]tetrahydro-N,N-dimethyl-, chloride (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Baba M, Nishimura O, et al. Proc Natl Acad Sci U S A. 1999 May 11;96(10):5698-703.
2. Shiraishi M, et al. J Med Chem. 2000 May 18;43(10):2049-63.
3. Gorry PR, et al. J Virol. 2002 Jun;76(12):6277-92.
4. Nedjai B, et al. Br J Pharmacol. 2015 Apr;172(7):1822-33.
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