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TAK-779
CAS No. 229005-80-5
TAK-779 ( TAK779;TAK 799;Takeda 779 )
Catalog No. M13635 CAS No. 229005-80-5
TAK-779 is a potent, specific, nonpeptide CCR5 antagonist with Kd of 0.45 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 80 | In Stock |
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| 10MG | 125 | In Stock |
|
| 25MG | 228 | In Stock |
|
| 50MG | 385 | In Stock |
|
| 100MG | 575 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTAK-779
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NoteResearch use only, not for human use.
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Brief DescriptionTAK-779 is a potent, specific, nonpeptide CCR5 antagonist with Kd of 0.45 nM.
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DescriptionTAK-779 is a potent, specific, nonpeptide CCR5 antagonist with Kd of 0.45 nM, antagonizes CCR2b to a lesser extent (27 nM) but does not affect CCR1, CCR3, or CCR4; also blocks the binding of macrophage inflammatory protein 1α and macrophage inflammatory protein 1β to the cells with an IC50 of 1.0 nM; TAK-779 displays highly potent and selective inhibition of the replication of macrophage (M)-tropic HIV-1 (Ba-L strain) in both MAGI-CCR5 cells and PBMCs with EC50 of 1.2 and 3.7 nM, respectively.HIV Infection Discontinued
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SynonymsTAK779;TAK 799;Takeda 779
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorHIV
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Research AreaInfection
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IndicationHIV Infection
Chemical Information
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CAS Number229005-80-5
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Formula Weight531.10
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Molecular FormulaC33H39ClN2O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 27 mg/mL
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SMILESCC1=CC=C(C=C1)C2=CC3=C(CCCC(=C3)C(=O)NC4=CC=C(C=C4)C[N+](C)(C)C5CCOCC5)C=C2.[Cl-]
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Chemical Name2H-Pyran-4-aminium, N-[[4-[[[6,7-dihydro-2-(4-methylphenyl)-5H-benzocyclohepten-8-yl]carbonyl]amino]phenyl]methyl]tetrahydro-N,N-dimethyl-, chloride (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Baba M, Nishimura O, et al. Proc Natl Acad Sci U S A. 1999 May 11;96(10):5698-703.
2. Shiraishi M, et al. J Med Chem. 2000 May 18;43(10):2049-63.
3. Gorry PR, et al. J Virol. 2002 Jun;76(12):6277-92.
4. Nedjai B, et al. Br J Pharmacol. 2015 Apr;172(7):1822-33.
2. Shiraishi M, et al. J Med Chem. 2000 May 18;43(10):2049-63.
3. Gorry PR, et al. J Virol. 2002 Jun;76(12):6277-92.
4. Nedjai B, et al. Br J Pharmacol. 2015 Apr;172(7):1822-33.
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