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TAK-715
CAS No. 303162-79-0
TAK-715( TAK 715 | TAK715 )
Catalog No. M13955 CAS No. 303162-79-0
A potent, selective, orally active p38α MAPK inhibitor with IC50 of 7.1 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 43 | In Stock |
|
| 5MG | 71 | In Stock |
|
| 10MG | 90 | In Stock |
|
| 25MG | 160 | In Stock |
|
| 50MG | 306 | In Stock |
|
| 100MG | 480 | In Stock |
|
| 500MG | 1071 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTAK-715
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, orally active p38α MAPK inhibitor with IC50 of 7.1 nM.
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DescriptionA potent, selective, orally active p38α MAPK inhibitor with IC50 of 7.1 nM; displays >20-fold selectvity over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1; inhibits LPS-stimulated release of TNF-alpha from THP-1 with IC50 of 48 nM; exerts significant efficacy in rat adjuvant-induced arthritis model.Rheumatoid Arthritis Phase 2 Discontinued.
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In Vitro——
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In VivoAnimal Model:7-week-old male Lewis rats with arthritis Dosage:3, 10, 30 mg/kg Administration:PO; single dose Result:Significantly reduced the secondary paw volume (25% inhibition).Animal Model:Rat Dosage:10 mg/kg (Pharmacokinetic Analysis)Administration:PO Result:Had a Cmax of 0.19 μg/mL and an AUC of 1.16 μg?h/mL.
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SynonymsTAK 715 | TAK715
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PathwayMAPK/ERK Signaling
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Targetp38 MAPK
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RecptorJNK1| p38α| p38β| p38γ| p38δ
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Research AreaInflammation/Immunology
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IndicationRheumatoid Arthritis
Chemical Information
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CAS Number303162-79-0
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Formula Weight399.508
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Molecular FormulaC24H21N3OS
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(NC1=NC=CC(C2=C(C3=CC=CC(C)=C3)N=C(CC)S2)=C1)C4=CC=CC=C4
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Chemical NameBenzamide, N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Miwatashi S, et al. J Med Chem. 2005 Sep 22;48(19):5966-79.
2. Verkaar F, et al. Chem Biol. 2011 Apr 22;18(4):485-94.
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