T326 ( T 326;HDAC3 inhibitor T326 )

Catalog No. M11945 CAS No. 1451042-19-5

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Product Name

T326
Note

Research use only, not for human use.
Brief Description

A potent and selective HDAC3 inhibitor with IC50 of 0.26 uM.
Description

A potent and selective HDAC3 inhibitor with IC50 of 0.26 uM, with no activity against HDAC1/4/6/8; induces dose-dependent selective increase of NF-κB acetylation in human colon cancer HCT116 cells, induces growth inhibition of cancer cells, and activates HIV gene expression in latent HIV-infected cells; shows promising activity for anticancer and antiviral benefits.
Synonyms

T 326;HDAC3 inhibitor T326
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC
Research Area

——
Indication

——

CAS Number

1451042-19-5
Formula Weight

434.47
Molecular Formula

C21H18N6O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=CC=C(C2=CN(CCC3=CC=CC([N+]([O-])=O)=C3)N=N2)S1)NC4=CC=CC=C4N
Chemical Name

N-(2-aminophenyl)-5-(1-(3-nitrophenethyl)-1H-1,2,3-triazol-4-yl)thiophene-2-carboxamide

1. Suzuki T, et al. PLoS One. 2013 Jul 16;8(7):e68669.

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