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AMI-1
CAS No. 20324-87-2
AMI-1 ( AMI-1; AMI 1; AMI1; AMI-1 disodium salt. )
Catalog No. M13165 CAS No. 20324-87-2
A specific inhibitor of PRMTs (protein arginine methyltransferases), but not lysine methyltransferases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 39 | In Stock |
|
| 10MG | 58 | In Stock |
|
| 25MG | 115 | In Stock |
|
| 50MG | 170 | In Stock |
|
| 100MG | 267 | In Stock |
|
| 500MG | 646 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAMI-1
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NoteResearch use only, not for human use.
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Brief DescriptionA specific inhibitor of PRMTs (protein arginine methyltransferases), but not lysine methyltransferases.
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DescriptionA specific inhibitor of PRMTs (protein arginine methyltransferases), but not lysine methyltransferases; inhibits PRMT1 and Hmt1p with IC50s of 8.81 uM and 3.03 uM respectively; increases the ratio of Bax/Bcl-2, and leads to apoptosis and loss of migratory activity in several HCC cells,decreases the expression levels of H4R3me2s; strongly inhibits HCC growth in vivo.
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SynonymsAMI-1; AMI 1; AMI1; AMI-1 disodium salt.
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorPRMT1;yeastHmt1p
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number20324-87-2
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Formula Weight548.45
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Molecular FormulaC21H14N2Na2O9S2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 46 mg/mL
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SMILESO=C(NC1=CC2=CC(S(=O)([O-])=O)=CC(O)=C2C=C1)NC3=CC4=CC(S(=O)([O-])=O)=CC(O)=C4C=C3.[Na+].[Na+]
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Chemical Name2-Naphthalenesulfonic acid, 7,7'-(carbonyldiimino)bis[4-hydroxy-, sodium salt (1:2)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Cheng D, et al. J Biol Chem. 2004 Jun 4;279(23):23892-9.
2. Zhang B, et al. Oncotarget. 2015 Sep 8;6(26):22799-811.
3. Zhang B, et al. J Transl Med. 2015 Nov 5;13:349.
2. Zhang B, et al. Oncotarget. 2015 Sep 8;6(26):22799-811.
3. Zhang B, et al. J Transl Med. 2015 Nov 5;13:349.
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