Cart
sales@molnova.com
AZ505
CAS No. 1035227-43-0
AZ505( AZ-505 | AZ 505 )
Catalog No. M10174 CAS No. 1035227-43-0
AZ505 (AZ-505, AZ 505) is a potent and selective inhibitor of protein lysine methyltransferase SMYD2 with IC50 of 0.12 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 87 | In Stock |
|
| 5MG | 147 | In Stock |
|
| 10MG | 237 | In Stock |
|
| 25MG | 401 | In Stock |
|
| 50MG | 591 | In Stock |
|
| 100MG | 842 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameAZ505
-
NoteResearch use only, not for human use.
-
Brief DescriptionAZ505 (AZ-505, AZ 505) is a potent and selective inhibitor of protein lysine methyltransferase SMYD2 with IC50 of 0.12 uM.
-
DescriptionAZ505 (AZ-505, AZ 505) is a potent and selective inhibitor of protein lysine methyltransferase SMYD2 with IC50 of 0.12 uM, displays >600-fold against other histone methyltransferases, such as SMYD3 and EZH2; suppresses BMP2-induced SMAD1/5 phosphorylation, delays cyst growth in both early- and later-stage Pkd1 conditional knockout mouse models; also significantly reduced tumor growth in vivo in triple-negative breast cancer (TNBC) models.
-
In Vitro——
-
In Vivo——
-
SynonymsAZ-505 | AZ 505
-
PathwayChromatin/Epigenetic
-
TargetHMTase
-
RecptorHMTase
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number1035227-43-0
-
Formula Weight577.5424
-
Molecular FormulaC29H38Cl2N4O4
-
Purity>98% (HPLC)
-
SolubilityDMSO : ≥ 42 mg/mL72.72 mM
-
SMILESC1CCC(CC1)N(CCNCCC2=C3C(=C(C=C2)O)NC(=O)CO3)C(=O)CCNCCC4=CC(=C(C=C4)Cl)Cl
-
Chemical NamePropanamide, N-cyclohexyl-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-N-[2-[[2-(3,4-dihydro-5-hydroxy-3-oxo-2H-1,4-benzoxazin-8-yl)ethyl]amino]ethyl]-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Ferguson AD, et al. Structure. 2011 Sep 7;19(9):1262-73.
2. Gao S, et al. J Biol Chem. 2017 Jul 28;292(30):12702-12712.
3. Li LX, et al. J Clin Invest. 2017 Jun 30;127(7):2751-2764.
4. Li LX, et al. Cell Death Dis. 2018 Feb 27;9(3):326.
molnova catalog
related products
-
EPZ-011989 trifluoro...
A potent, selective, orally bioavailable inhibitor of EZH2 with Ki of < 3 nM.
-
MI-2-2 hydrochloride
MI-2-2 hydrochloride is a potent inhibitor of the menin-MLL interaction that binds to menin with low nanomolar affinity (Kd=22 nM).
-
CN-SAH
CN-SAH is a potent and selective inhibitor of histone methyl transferase DOT1L with IC50 of 26 nM.
