Stattic

CAS No. 19983-44-9

Stattic( STAT3 Inhibitor V )

Catalog No. M13121 CAS No. 19983-44-9

Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM, highly selectivity over STAT1.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 69 In Stock
50MG 113 In Stock
100MG 177 In Stock
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Biological Information

  • Product Name
    Stattic
  • Note
    Research use only, not for human use.
  • Brief Description
    Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM, highly selectivity over STAT1.
  • Description
    Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM, highly selectivity over STAT1.(In Vitro):Stattic (20 μM; 24 hours) inhibits STAT3 phosphorylation (Y705) and selectively inhibits P-STAT3 as demonstrated by the lack of inhibition of P-ERK1/2 in ALDH+ and D44+/CD24+ subpopulations of Panc-1 and HPAC pancreatic cancer cell lines.Stattic (2.5, 5, 10 μM; for 4 h) significantly reduces the nuclear level of pSTAT3 and survivin in PC3M-1E8 cells at 10 μM. Stattic (2.5-10 μM; for 24 h) inhibits IL-6-induced STAT3 activation in a dose-dependent manner.Stattic (2.5, 5, 10 μM; for 48 h) suppresses both the growth and induces apoptosis prostate cancer cells (PC3M-1E8 cells) with 10 μM. Stattic does not induce significant cell apoptosis with 2.5 μM, 5 μM.Stattic (2.5, 5, 10 μM; for 48 h) shows significant S phase accumulation.Stattic can not lead to significant morphological changes or apoptosis and has little STAT3 phosphorylation in A2780 cells and HUVECs.(In Vivo):Stattic (10 mg/kg; i.p.; three times per week for 10 week) ameliorates the renal dysfunction in Alport syndrome (AS) mice.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Age-matched wild-type (WT) C57BL/6 miceDosage:10 mg/kg Administration:IP; three timesper week for 10 week Result:Increased levels of proteinuria, BUN and serum creatinine.Significantly suppressed the gene expression levels of renal injury markers (Lcn2, Kim-1), pro-inflammatory cytokines (Il-6, KC), pro-fibrotic genes (Tgf-β, Col1a1, α-Sma) and Mmp9.
  • Synonyms
    STAT3 Inhibitor V
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT3
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    19983-44-9
  • Formula Weight
    211.19
  • Molecular Formula
    C8H5NO4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 42 mg/mL (198.87 mM)
  • SMILES
    O=[N+](C1=CC=C(C2=C1)C=CS2(=O)=O)[O-]
  • Chemical Name
    6-Nitro-1-benzothiophene 1,1-dioxide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Schust J, et al. Chem Biol, 2006, 13(11), 1235-1242.
molnova catalog
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