BP-1-102

Research use only, not for human use.

An orally bioavailable, small-molecule inhibitor of STAT3 with Kd of 504 nM.

An orally bioavailable, small-molecule inhibitor of STAT3 with Kd of 504 nM; blocks Stat3-pTyr peptide interactions and Stat3 activation at 4-6.8 uM, and selectively inhibits growth, survival, migration, and invasion of Stat3-dependent tumor cells; suppresses the expression of c-Myc, Cyclin D1, Bcl-xL, Survivin, VEGF, and KLF8, blocks Stat3-NF-κB cross-talk, and enhances E-cadherin expression; inhibits growth of human breast and lung tumor xenografts.

BP-1-102; BP1-102; BP 1-102; BP1102

JAK/STAT Signaling

STAT

STAT3

Cancer

——

1334493-07-0

626.59

C29H27F5N2O6S

>98% (HPLC)

DMSO: ≥ 33 mg/mL

O=C(O)C1=CC=C(N(CC2=CC=C(C3CCCCC3)C=C2)C(CN(C)S(=O)(C4=C(F)C(F)=C(F)C(F)=C4F)=O)=O)C=C1O

Benzoic acid, 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-2-hydroxy-

(-20℃)

With Ice Pack

≥ 2 years