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Home - Products - JAK/STAT Signaling - STAT - Stafib-2

Stafib-2

CAS No. 2097938-74-2

Stafib-2( Stafib 2 )

Catalog No. M13314 CAS No. 2097938-74-2

Stafib-2 (Stafib 2)?is a potent, selective small molecule inhibitor of transcription factor STAT5b with Ki of 9 nM, >20-fold selectivity over STAT5a.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Stafib-2
  • Note
    Research use only, not for human use.
  • Brief Description
    Stafib-2 (Stafib 2)?is a potent, selective small molecule inhibitor of transcription factor STAT5b with Ki of 9 nM, >20-fold selectivity over STAT5a.
  • Description
    Stafib-2 (Stafib 2)?is a potent, selective small molecule inhibitor of transcription factor STAT5b with Ki of 9 nM, >20-fold selectivity over STAT5a.
  • In Vitro
    Stafib-2 has an extremely high affinity for STAT5b (Ki=8.8 nM).Stafib-2 (3-10 μM; 4-48 h) does not show significant activity in K562 and MDA-MB-231 cells.
  • In Vivo
    ——
  • Synonyms
    Stafib 2
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2097938-74-2
  • Formula Weight
    644.466
  • Molecular Formula
    C28H26N2O12P2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (77.58 mM)
  • SMILES
    ——
  • Chemical Name
    4-((2-(4-((4-phenoxyphenyl)carbamoyl)phenoxy)acetamido)methyl)-1,2-phenylene bis(dihydrogen phosphate)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Elumalai N, et al. Sci Rep. 2017 Apr 11;7(1):819.
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