Stafib-1( Stafib 1 )

Catalog No. M12577 CAS No. 1688703-26-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Stafib-1
Note

Research use only, not for human use.
Brief Description

A potent, selective small molecule inhibitor of transcription factor STAT5b with Ki of 44 nM.
Description

A potent, selective small molecule inhibitor of transcription factor STAT5b with Ki of 44 nM, >50-fold selectivity over STAT5a.
In Vitro

Stafib-1 is the first small molecule which inhibits the STAT5b SH2 domain with more than 50-fold selectivity over STAT5a.
In Vivo

——
Synonyms

Stafib 1
Pathway

JAK/STAT Signaling
Target

STAT
Recptor

STAT
Research Area

Cancer
Indication

——

CAS Number

1688703-26-5
Formula Weight

602.429
Molecular Formula

C26H24N2O11P2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (166.00 mM)
SMILES

O=C(NCC1=CC=C(OP(O)(O)=O)C(OP(O)(O)=O)=C1)COC2=CC=C3C=C(C(NC4=CC=CC=C4)=O)C=CC3=C2
Chemical Name

4-((2-((6-(phenylcarbamoyl)naphthalen-2-yl)oxy)acetamido)methyl)-1,2-phenylene bis(dihydrogen phosphate)

1. Elumalai N, et al. Angew Chem Int Ed Engl. 2015 Apr 13;54(16):4758-63. 2. Elumalai N, et al. Sci Rep. 2017 Apr 11;7(1):819.

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