
Stafib-1
CAS No. 1688703-26-5
Stafib-1( Stafib 1 )
Catalog No. M12577 CAS No. 1688703-26-5
A potent, selective small molecule inhibitor of transcription factor STAT5b with Ki of 44 nM.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
100MG | Get Quote | Get Quote |
![]() ![]() |
200MG | Get Quote | Get Quote |
![]() ![]() |
500MG | Get Quote | Get Quote |
![]() ![]() |
1G | Get Quote | Get Quote |
![]() ![]() |
Biological Information
-
Product NameStafib-1
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective small molecule inhibitor of transcription factor STAT5b with Ki of 44 nM.
-
DescriptionA potent, selective small molecule inhibitor of transcription factor STAT5b with Ki of 44 nM, >50-fold selectivity over STAT5a.
-
In VitroStafib-1 is the first small molecule which inhibits the STAT5b SH2 domain with more than 50-fold selectivity over STAT5a.
-
In Vivo——
-
SynonymsStafib 1
-
PathwayJAK/STAT Signaling
-
TargetSTAT
-
RecptorSTAT
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number1688703-26-5
-
Formula Weight602.429
-
Molecular FormulaC26H24N2O11P2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (166.00 mM)
-
SMILESO=C(NCC1=CC=C(OP(O)(O)=O)C(OP(O)(O)=O)=C1)COC2=CC=C3C=C(C(NC4=CC=CC=C4)=O)C=CC3=C2
-
Chemical Name4-((2-((6-(phenylcarbamoyl)naphthalen-2-yl)oxy)acetamido)methyl)-1,2-phenylene bis(dihydrogen phosphate)
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Elumalai N, et al. Angew Chem Int Ed Engl. 2015 Apr 13;54(16):4758-63.
2. Elumalai N, et al. Sci Rep. 2017 Apr 11;7(1):819.
molnova catalog



related products
-
FLLL-32
FLLL-32 is a cell-permeable analog of curcumin that inhibits JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells (IC50=5 uM).
-
C188-9 (b)
A novel small-molecule STAT3 inhibitor with Ki of 12.4 nM; inhibits STAT3 binding to its pY-peptide ligand.
-
Fludarabine
Fludarabine(NSC 118218), a DNA synthesis inhibitor.