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Stafib-1

CAS No. 1688703-26-5

Stafib-1( Stafib 1 )

Catalog No. M12577 CAS No. 1688703-26-5

A potent, selective small molecule inhibitor of transcription factor STAT5b with Ki of 44 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Stafib-1
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective small molecule inhibitor of transcription factor STAT5b with Ki of 44 nM.
  • Description
    A potent, selective small molecule inhibitor of transcription factor STAT5b with Ki of 44 nM, >50-fold selectivity over STAT5a.
  • In Vitro
    Stafib-1 is the first small molecule which inhibits the STAT5b SH2 domain with more than 50-fold selectivity over STAT5a.
  • In Vivo
    ——
  • Synonyms
    Stafib 1
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1688703-26-5
  • Formula Weight
    602.429
  • Molecular Formula
    C26H24N2O11P2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (166.00 mM)
  • SMILES
    O=C(NCC1=CC=C(OP(O)(O)=O)C(OP(O)(O)=O)=C1)COC2=CC=C3C=C(C(NC4=CC=CC=C4)=O)C=CC3=C2
  • Chemical Name
    4-((2-((6-(phenylcarbamoyl)naphthalen-2-yl)oxy)acetamido)methyl)-1,2-phenylene bis(dihydrogen phosphate)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Elumalai N, et al. Angew Chem Int Ed Engl. 2015 Apr 13;54(16):4758-63. 2. Elumalai N, et al. Sci Rep. 2017 Apr 11;7(1):819.
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