STAT5-IN-1

CAS No. 285986-31-4

STAT5-IN-1( Signal Transducers and Activators of Transcription 5 )

Catalog No. M13870 CAS No. 285986-31-4

A selective, small molecule inhibitor of the transcription factor STAT5 with IC50 of 47±17 uM in FP assays.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 77 In Stock
25MG 165 In Stock
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Biological Information

  • Product Name
    STAT5-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    A selective, small molecule inhibitor of the transcription factor STAT5 with IC50 of 47±17 uM in FP assays.
  • Description
    A selective, small molecule inhibitor of the transcription factor STAT5 with IC50 of 47±17 uM in FP assays; shows little to no inhibition for STAT1, STAT3 and Lck (<40% inhibition at 500 uM); selectively inhibits the function of the STAT5b domain and STAT5 DNA binding in vitro, and selectively inhibits activation of STAT5 in K562 cells.
  • In Vitro
    The signal transducer and activator of transcription 5 (STAT5) is a member of the STAT family of proteins, implicated in cell growth and differentiation. STAT5-IN-1 inhibits STAT5 by binding to the SH2 domain. The functions of the SH2 domains of STAT3, STAT1, and of the tyrosine kinase Lck are inhibited to a lesser extent (IC50>500 μM). STAT5-IN-1 block STAT5/STAT5 DNA binding in K562 nuclear extracts. Substitution of the hydrogen at C6 of the chromone ring by an ethyl group does not affect activity of STAT5-IN-1 against STAT5β, but leads to complete loss of selectivity against other STAT family members.
  • In Vivo
    ——
  • Synonyms
    Signal Transducers and Activators of Transcription 5
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT5β
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    285986-31-4
  • Formula Weight
    293.28
  • Molecular Formula
    C16H11N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥23.0 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    O=C(N/N=C/C1=COC2=C(C=CC=C2)C1=O)C3=CN=CC=C3
  • Chemical Name
    3-Pyridinecarboxylic acid, [(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazide (9CI)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Müller J, et al. Chembiochem. 2008 Mar 25; 9(5):723-7.
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