Sophocarpine

Research use only, not for human use.

Sophocarpine has anti-cancer, anti-inflammatory, anti-nociceptive, and antivirus activities, it can prevent implant loosening through inhibiting osteoclast formation and bone resorption.

Sophocarpine has anti-cancer, anti-inflammatory, anti-nociceptive, and antivirus activities, it can prevent implant loosening through inhibiting osteoclast formation and bone resorption, thus, it may be a novel therapeutic agent to prevent prosthesis loosening and for osteolytic diseases. Sophocarpine could attenuate ConA-induced liver injury, and the protective effect of Sophocarpine was associated with its inhibition effect of pro-inflammatory cytokines, chemokines, and the IFN-γ/STAT1 signaling pathway.(In Vitro):To investigate the antiviral effect of thymopolypeptides combined with 4 kinds of matrine type alkaloids on HepG2.2.15 cells, oxymatrine, sophocarpidine, Sophocarpine, and sophoridine (at concentration of 0.2 mmol/L; respectively) were respectively combined with thymopolypeptides (0.025, 0.1 g/L), and after 48 h and 72 h treatment on HepG2.2.15 cells, the cells and supernatants were collected. The cells activity in various groups was determined by CCK-8 method to evaluate the toxic effects of the drugs on HepG2.2.15 cells. Enzyme linked immunosorbent assay (ELISA) was used to determine HBeAg and HBsAg levels in cellular supernatants. HBV DNA levels in cellular supernatants andcells were quantified with fluorogenic quantitative PCR method; and the expression level of IFN-α in supernatants was detected with CBA method. The results indicated that single thymopolypeptides at 0.025-0.4 g/L; had no toxicity to cells. Thymopolypeptides in this concentration range combined with 0.2 mmol/L; matrine type alkaloids also had no toxicity to cells. Anti-HBV activity of drug combination was better than that of alkali or thymopolypeptides alone. Thymopolypeptides at 0.025 g/L; had better inhibitory effect than thymopolypeptides at 0.1 g/L; on intracellular HBV DNA expression, but the inhibitory effect on supernatant HBeAg level was on the contrary. Anti-HBV activity was similar between alkaloids combined with 0.1 g/L; and alkaloids combined with 0.025 g/L;. There was no statistical difference in anti-HBV effect between various combined groups (P<0.05). In general, 72 h anti-HBV effect was better than 48 h anti-HBV effect (P<0.05). The expression of IFN-α was increased after drug combination, with positive correlation to the changes of other four indicators (P<0.05).(In Vivo):Inoculation (s.c.) of colon26 adenocarcinoma cells into BALB/c mice induced cachexia, as evidenced by progressive weight loss, reduction in food intake, wasting of gastrocnemius muscle and epididymal fat, and increase in serum levels of TNF-alpha and IL-6. Administration of 50 mg/kg/d sophocarpine or matrine for 5 days from the onset of cachexia did not inhibit the tumor growth but resulted in attenuation of cachexia symptoms. Furthermore, sophocarpine and matrine decreased the serum levels of TNF-alpha and IL-6, and sophocarpine showed a better therapeutic effect than matrine.

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Apoptosis

PERK

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6483-15-4

246.4

C15H22N2O

>98% (HPLC)

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O=C(C=CC1)N(C[C@@H]2CCC3)[C@H]1[C@@H]1[C@H]2N3CCC1

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(-20℃)

With Ice Pack

≥ 2 years