Fustin

Research use only, not for human use.

Fustin is the phytogenic flavanol component of the plant Rhus verniciflua Stokes. Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death.

Fustin is the phytogenic flavanol component of the plant Rhus verniciflua Stokes. Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death.(In Vivo): In diabetic male rats, the behavioral parameters with MWM and EPM were significantly restored in fustin(50 mg/kg and 100 mg/kg) treatment groups as compared to elevated levels in the diabetic control group.

——

Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) attenuates Aβ (1-42)-induced impairments in conditioned fear learning and passive avoidance behavior.Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) alters Aβ (1-42)-induced changes in ACh level and AChE and ChAT activity and gene expression.Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) increases Aβ (1-42)-induced reduction in M1 receptor mRNA and protein expression in Aβ-treated C57BL/6 mice. Fustin increases p-ERK and p-CREB expression in Aβ-treated C57BL/6 mice. Animal Model:Aβ-treated C57BL/6 mice Dosage:50 and 100 mg/kg Administration:Oral administration;daily, for 11days Result:Decreased freezing response in Aβ-treated C57BL/6 mice.Animal Model:Aβ-treated C57BL/6 mice Dosage:50 and 100 mg/kg Administration:Oral administration;daily, for 11days Result:Increased the expression of Ach, ChAT gene and ChAT activity. Decreased the expression of AChE gene and AChE activity.Animal Model:Aβ-treated C57BL/6 mice Dosage:50 and 100 mg/kg Administration:Oral administration;daily, for 11days Result:Increased gene expression of M2- , M3- ,M4-, M5-, α4β, α7-receptor, p-ERK and p-CREB.

Dihydrofisetin

Apoptosis

PERK

ERK

——

——

20725-03-5

288.255

C15H12O6

>98% (HPLC)

——

O[C@@H]1[C@H](Oc2cc(O)ccc2C1=O)c1ccc(O)c(O)c1

——

(-20℃)

With Ice Pack

≥ 2 years