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CCT020312
CAS No. 324759-76-4
CCT020312( —— )
Catalog No. M33308 CAS No. 324759-76-4
CCT020312 (0-9 μM, 24 h) treatment of medium HT29 cells for 24 h resulted in a concentration-dependent loss of P-S608-pRB signaling with linear response values between 1.8 and 6.1 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 85 | Get Quote |
|
| 5MG | 136 | Get Quote |
|
| 10MG | 240 | Get Quote |
|
| 25MG | 395 | Get Quote |
|
| 50MG | 584 | Get Quote |
|
| 100MG | 795 | Get Quote |
|
| 500MG | 1647 | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameCCT020312
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NoteResearch use only, not for human use.
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Brief DescriptionCCT020312 (0-9 μM, 24 h) treatment of medium HT29 cells for 24 h resulted in a concentration-dependent loss of P-S608-pRB signaling with linear response values between 1.8 and 6.1 μM.
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DescriptionCCT020312 is a selective EIF2AK3/PERK activator. CCT020312 elicits EIF2A phosphorylation in cells.
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In Vitro——
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In VivoAnimal Model:9-week-old P301S tau transgenic mice Dosage:2 mg/kg Administration:Intraperitoneal injection; once daily for 6 weeks Result:P301S transgenic mice treated with CCT020312 performed significantly better in Morris water maze.
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Synonyms——
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PathwayApoptosis
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TargetPERK
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RecptorPERK
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Research Area——
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Indication——
Chemical Information
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CAS Number324759-76-4
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Formula Weight650.4
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Molecular FormulaC31H30Br2N4O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (153.75 mM; Ultrasonic )
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SMILESCCN(CC)CCC(=O)N1N=C(CC1c1ccc(Br)cc1)c1c(-c2ccccc2)c2cc(Br)ccc2[nH]c1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Stockwell SR, et al.Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling. PLoS One. 2012;7(1):e28568.?
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