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CCT020312

CAS No. 324759-76-4

CCT020312( —— )

Catalog No. M33308 CAS No. 324759-76-4

CCT020312 (0-9 μM, 24 h) treatment of medium HT29 cells for 24 h resulted in a concentration-dependent loss of P-S608-pRB signaling with linear response values between 1.8 and 6.1 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CCT020312
  • Note
    Research use only, not for human use.
  • Brief Description
    CCT020312 (0-9 μM, 24 h) treatment of medium HT29 cells for 24 h resulted in a concentration-dependent loss of P-S608-pRB signaling with linear response values between 1.8 and 6.1 μM.
  • Description
    CCT020312 is a selective EIF2AK3/PERK activator. CCT020312 elicits EIF2A phosphorylation in cells.
  • In Vitro
    ——
  • In Vivo
    Animal Model:9-week-old P301S tau transgenic mice Dosage:2 mg/kg Administration:Intraperitoneal injection; once daily for 6 weeks Result:P301S transgenic mice treated with CCT020312 performed significantly better in Morris water maze.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    PERK
  • Recptor
    PERK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    324759-76-4
  • Formula Weight
    650.4
  • Molecular Formula
    C31H30Br2N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (153.75 mM; Ultrasonic )
  • SMILES
    CCN(CC)CCC(=O)N1N=C(CC1c1ccc(Br)cc1)c1c(-c2ccccc2)c2cc(Br)ccc2[nH]c1=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Stockwell SR, et al.Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling. PLoS One. 2012;7(1):e28568.?
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