Simotinib( SIM6802 | SIM-6802 )

Catalog No. M16764 CAS No. 944258-89-3

COA

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HNMR

HPLC

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Product Name

Simotinib
Note

Research use only, not for human use.
Brief Description

Simotinib (SIM-6802) is a novel potent EGFR inhibitor for treatment of NSCLC.
Description

Simotinib (SIM-6802) is a novel potent EGFR inhibitor for treatment of NSCLC.Lung Cancer Phase 1 Clinical.
In Vitro

Simotinib inhibits in a dose-dependent manner EGFR and the growth of human A431 tumor cells with high expression of EGFR, with no significant activity on other investigated kinases.
In Vivo

Simotinib has been shown to exert its antitumor activity by inhibiting EGFR phosphorylation in nude xenograft model.
Synonyms

SIM6802 | SIM-6802
Pathway

Angiogenesis
Target

EGFR
Recptor

EGFR
Research Area

Cancer
Indication

Lung Cancer

CAS Number

944258-89-3
Formula Weight

500.95
Molecular Formula

C25H26ClFN4O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (249.53 mM)
SMILES

COC1=C(OCCN2CC3(C4(OCCO4)C2)CC3)C=C(C(NC5=CC=C(F)C(Cl)=C5)=NC=N6)C6=C1
Chemical Name

N-(3-chloro-4-fluorophenyl)-6-(2-(5,8-dioxa-11-azadispiro(2.0.4.3)undec-11-yl)ethoxy)-7-methoxy-4-quinazolinamine

1. Huang L, et al. Anticancer Drugs. 2016 Apr;27(4):300-11.

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