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HS-10296 hydrochloride
CAS No. 2134096-03-8
HS-10296 hydrochloride( —— )
Catalog No. M20331 CAS No. 2134096-03-8
HS-10296 hydrochloride is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 240 | In Stock |
|
| 5MG | 185 | In Stock |
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| 10MG | 312 | In Stock |
|
| 25MG | 537 | In Stock |
|
| 50MG | 737 | In Stock |
|
| 100MG | 1004 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameHS-10296 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionHS-10296 hydrochloride is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.
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DescriptionHS-10296 hydrochloride is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.(In Vitro):Almonertinib (HS-10296) is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity, which canbe used to treat NSCLC. Additionaly, Almonertinib (HS-10296) could also inhibit other EGFR sensitive mutations, including G719X, del19, L858R and L861Q.
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In VitroAlmonertinib (HS-10296) is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity, which canbe used to treat NSCLC. Additionaly, Almonertinib (HS-10296) could also inhibit other EGFR sensitive mutations, including G719X, del19, L858R and L861Q.
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR
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Research AreaCancer
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IndicationNon-small cell lung Cancer
Chemical Information
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CAS Number2134096-03-8
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Formula Weight562.1
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Molecular FormulaC30H36ClN7O2
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Purity>98% (HPLC)
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SolubilityDMSO:83.33 mg/mL (148.25 mM; Need ultrasonic)
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SMILESCl.COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cn(C2CC2)c2ccccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ivana S David P . Next-Generation EGFR Tyrosine Kinase Inhibitors for Treating EGFR-Mutant Lung Cancer beyond First Line[J]. Frontiers in Medicine 2017 3.
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