Sigma-LIGAND-1( —— )

Catalog No. M33195 CAS No. 139652-01-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Sigma-LIGAND-1
Note

Research use only, not for human use.
Brief Description

Sigma-LIGAND-1 is a selective Sigma Receptor ligand with IC50 values of 16 nM and 19 nM at the DTG site and the PPP site, respectively, and a Ki of 4000 nM at the dopamine D2 receptor.
Description

Sigma-LIGAND-1 is a selective sigma receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma-LIGAND-1 has a Ki of 4000 nM at the dopamine D2 receptor.
In Vitro

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In Vivo

Administration of Sigma-LIGAND-1 would reverse amphetamine-induced hyperlocomotion in mice, a behavioral model sensitive to antipsychotic compounds. Sigma-LIGAND-1 and its structural analogues have the potential antipsychotic activity.
Synonyms

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Pathway

Autophagy
Target

Sigma receptor
Recptor

Sigma receptor
Research Area

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Indication

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1. Erickson RH, et al. (Aminoalkoxy)chromones. Selective sigma receptor ligands. J Med Chem. 1992 May 1;35(9):1526-35.?

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