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Sigma-LIGAND-1

CAS No. 139652-01-0

Sigma-LIGAND-1( —— )

Catalog No. M33195 CAS No. 139652-01-0

Sigma-LIGAND-1 is a selective Sigma Receptor ligand with IC50 values of 16 nM and 19 nM at the DTG site and the PPP site, respectively, and a Ki of 4000 nM at the dopamine D2 receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Sigma-LIGAND-1
  • Note
    Research use only, not for human use.
  • Brief Description
    Sigma-LIGAND-1 is a selective Sigma Receptor ligand with IC50 values of 16 nM and 19 nM at the DTG site and the PPP site, respectively, and a Ki of 4000 nM at the dopamine D2 receptor.
  • Description
    Sigma-LIGAND-1 is a selective sigma receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma-LIGAND-1 has a Ki of 4000 nM at the dopamine D2 receptor.
  • In Vitro
    ——
  • In Vivo
    Administration of Sigma-LIGAND-1 would reverse amphetamine-induced hyperlocomotion in mice, a behavioral model sensitive to antipsychotic compounds. Sigma-LIGAND-1 and its structural analogues have the potential antipsychotic activity.
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    Sigma receptor
  • Recptor
    Sigma receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    139652-01-0
  • Formula Weight
    435.56
  • Molecular Formula
    C27H33NO4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (229.59 mM; Ultrasonic )
  • SMILES
    Cc1c(oc2ccc(OCCCCCCN3CCC(O)CC3)cc2c1=O)-c1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Erickson RH, et al. (Aminoalkoxy)chromones. Selective sigma receptor ligands. J Med Chem. 1992 May 1;35(9):1526-35.?
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