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KB-5492 free base
CAS No. 113594-64-2
KB-5492 free base( —— )
Catalog No. M35637 CAS No. 113594-64-2
KB-5492 free base is an orally available and selective antiulcer agent that inhibits sigma receptors, inhibits [3H]1,3-di(2-tolyl)guanidine (DTG) binding to sigma receptors, and may be useful in the study of gastric lesions and gastric secretion.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 59 | In Stock |
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| 2MG | 33 | In Stock |
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| 5MG | 53 | In Stock |
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| 10MG | 75 | In Stock |
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| 25MG | 122 | In Stock |
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| 50MG | 174 | In Stock |
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| 100MG | 257 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | 634 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameKB-5492 free base
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NoteResearch use only, not for human use.
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Brief DescriptionKB-5492 free base is an orally available and selective antiulcer agent that inhibits sigma receptors, inhibits [3H]1,3-di(2-tolyl)guanidine (DTG) binding to sigma receptors, and may be useful in the study of gastric lesions and gastric secretion.
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DescriptionKB-5492 free base is a potent and selective inhibitor of sigma receptor, inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM. KB-5492 free base is an anti-ulcer agent.
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In VitroKB-5492 (0.001-100 μM) free base inhibits specific [3H]DTG binding in a concentration-dependent manner.KB-5492 (0.1-1 mM) free base significantly and concentration-dependently prevents the ethanol- and acidified aspirin-induced increases in 51Cr release from gastric epithelial cells.
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In VivoKB-5492 (200?mg/kg; p.o.) free base prevents macroscopic lesions in the gastric mucosa.Animal Model:Male Sprague-Dawley rats weighing 210-240 g are induced gastric mucosal damage Dosage:200?mg/kg Administration:Oral gavage Result:Reduced the lesion length as compared with the control.Prevented the deep mucosal lesions and exfoliation of surface epithelial cells.
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Synonyms——
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PathwayAutophagy
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TargetSigma receptor
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RecptorSigma receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number113594-64-2
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Formula Weight430.49
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Molecular FormulaC23H30N2O6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (232.29 mM; Ultrasonic )
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SMILESCOc1ccc(OC(=O)CN2CCN(Cc3cc(OC)c(OC)c(OC)c3)CC2)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Harada Y, et, al. Receptor binding profiles of KB-5492, a novel anti-ulcer agent, at sigma receptors in guinea-pig brain. Eur J Pharmacol. 1994 May 2; 256(3): 321-8.?
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