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BS-194

CAS No. 1092443-55-4

BS-194 ( BS 194;BS194 )

Catalog No. M10349 CAS No. 1092443-55-4

BS-194 is a potent, selective, orally bioactive CDK2 inhibitor with IC50 of 2.4 nM, displays 140-fold selectivity over CDK7 (IC50=378 nM); weakly inhibits CDK1, CDK5, CDK7, and CDK9 with IC50 of 30, 30, 250, and 90 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BS-194
  • Note
    Research use only, not for human use.
  • Brief Description
    BS-194 is a potent, selective, orally bioactive CDK2 inhibitor with IC50 of 2.4 nM, displays 140-fold selectivity over CDK7 (IC50=378 nM); weakly inhibits CDK1, CDK5, CDK7, and CDK9 with IC50 of 30, 30, 250, and 90 nM.
  • Description
    BS-194 is a potent, selective, orally bioactive CDK2 inhibitor with IC50 of 2.4 nM, displays 140-fold selectivity over CDK7 (IC50=378 nM); weakly inhibits CDK1, CDK5, CDK7, and CDK9 with IC50 of 30, 30, 250, and 90 nM; shows inhibition of the phosphorylation of CDK substrates, Rb and the RNA polymerase II C-terminal domain, down-regulation of cyclins A, E, and D1, and cell cycle block in the S and G2/M phases; inhibits human tumor xenografts and suppresses CDK substrate phosphorylation.
  • Synonyms
    BS 194;BS194
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1092443-55-4
  • Formula Weight
    385.47
  • Molecular Formula
    C20H27N5O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    OC[C@@H](O)[C@@H](NC1=NC2=C(C(C)C)C=NN2C(NCC3=CC=CC=C3)=C1)CO
  • Chemical Name
    (2S,3S)-3-[[7-(benzylamino)-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]butane-1,2,4-triol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hazel P, et al. ChemMedChem. 2017 Mar 7;12(5):372-380.
2. Tripathi SK, et al. J Mol Recognit. 2012 Oct;25(10):504-12.
3. Heathcote DA, et al. J Med Chem. 2010 Dec 23;53(24):8508-22.
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