![](../../files/images/goods/1092443-55-4.png)
BS-194
CAS No. 1092443-55-4
BS-194 ( BS 194;BS194 )
Catalog No. M10349 CAS No. 1092443-55-4
BS-194 is a potent, selective, orally bioactive CDK2 inhibitor with IC50 of 2.4 nM, displays 140-fold selectivity over CDK7 (IC50=378 nM); weakly inhibits CDK1, CDK5, CDK7, and CDK9 with IC50 of 30, 30, 250, and 90 nM.
Purity : >98% (HPLC)
![](/themes/theme/en/images/pdf.png)
![](/themes/theme/en/images/pdf.png)
![](/themes/theme/en/images/pdf.png)
![](/themes/theme/en/images/pdf.png)
![](/themes/theme/en/images/pdf.png)
![](/themes/theme/en/images/pdf.png)
Size | Price / USD | Stock | Quantity |
2MG | 137 | Get Quote |
![]() ![]() |
5MG | 206 | Get Quote |
![]() ![]() |
10MG | 309 | Get Quote |
![]() ![]() |
25MG | 521 | Get Quote |
![]() ![]() |
50MG | 746 | Get Quote |
![]() ![]() |
100MG | 1035 | Get Quote |
![]() ![]() |
200MG | Get Quote | Get Quote |
![]() ![]() |
500MG | Get Quote | Get Quote |
![]() ![]() |
1G | Get Quote | Get Quote |
![]() ![]() |
Biological Information
-
Product NameBS-194
-
NoteResearch use only, not for human use.
-
Brief DescriptionBS-194 is a potent, selective, orally bioactive CDK2 inhibitor with IC50 of 2.4 nM, displays 140-fold selectivity over CDK7 (IC50=378 nM); weakly inhibits CDK1, CDK5, CDK7, and CDK9 with IC50 of 30, 30, 250, and 90 nM.
-
DescriptionBS-194 is a potent, selective, orally bioactive CDK2 inhibitor with IC50 of 2.4 nM, displays 140-fold selectivity over CDK7 (IC50=378 nM); weakly inhibits CDK1, CDK5, CDK7, and CDK9 with IC50 of 30, 30, 250, and 90 nM; shows inhibition of the phosphorylation of CDK substrates, Rb and the RNA polymerase II C-terminal domain, down-regulation of cyclins A, E, and D1, and cell cycle block in the S and G2/M phases; inhibits human tumor xenografts and suppresses CDK substrate phosphorylation.
-
SynonymsBS 194;BS194
-
PathwayAngiogenesis
-
TargetCDK
-
RecptorCDK
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1092443-55-4
-
Formula Weight385.47
-
Molecular FormulaC20H27N5O3
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESOC[C@@H](O)[C@@H](NC1=NC2=C(C(C)C)C=NN2C(NCC3=CC=CC=C3)=C1)CO
-
Chemical Name(2S,3S)-3-[[7-(benzylamino)-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]butane-1,2,4-triol
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Hazel P, et al. ChemMedChem. 2017 Mar 7;12(5):372-380.
2. Tripathi SK, et al. J Mol Recognit. 2012 Oct;25(10):504-12.
3. Heathcote DA, et al. J Med Chem. 2010 Dec 23;53(24):8508-22.
2. Tripathi SK, et al. J Mol Recognit. 2012 Oct;25(10):504-12.
3. Heathcote DA, et al. J Med Chem. 2010 Dec 23;53(24):8508-22.
molnova catalog
![](/themes/theme/en/images/ct.png)
![](/themes/theme/en/images/ct2.png)
related products
-
YKL-5-124
YKL-5-124 is a novel potent, selective, and covalent CDK7 inhibitor (IC50=53.5 nM), inhibits CDK7/CycH/MAT1 enzymatic activity with IC50 of 9.7 nM.
-
(R)-CR8
(R)-CR8 is a potent and selective CDK inhibitor.A delayed systemic post-LFP administration at 3 hours of CR8--a potent second-generation cyclin-dependent kinase (CDK) inhibitor.
-
WAY-647802
WAY-647802 is a CDK inhibitor.