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Sabutoclax
CAS No. 1228108-65-3
Sabutoclax ( BI-97C1 )
Catalog No. M10887 CAS No. 1228108-65-3
Sabutoclax (BI-97C1) is a potent, pan Bcl-2 family proteins inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 709 | Get Quote |
|
| 100MG | 963 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameSabutoclax
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NoteResearch use only, not for human use.
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Brief DescriptionSabutoclax (BI-97C1) is a potent, pan Bcl-2 family proteins inhibitor.
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DescriptionSabutoclax (BI-97C1) is a potent, pan Bcl-2 family proteins inhibitor that inhibits the binding of BH3 peptides to Bcl-XL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31, 0.32, 0.20 and 0.62 uM; potently inhibits cell growth of human prostate cancer, lung cancer, and lymphoma cell lines withEC50 of 0.13, 0.56, and 0.049 uM, respectively; displays superior single-agent antitumor efficacy in prostate cancer mouse xenograft model.
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SynonymsBI-97C1
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PathwayAngiogenesis
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TargetBcl-2
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RecptorMcl-1 , Bcl-xL , Bcl-2 , Bfl-1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1228108-65-3
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Formula Weight700.79
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Molecular FormulaC42H40N2O8
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Purity>98% (HPLC)
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SolubilityMethanol : 75 mg/mL 107.02 mM
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SMILESO=C(C1=C(O)C(O)=CC2=C(O)C(C3=C(C)C=C4C(C(NC[C@@H](C5=CC=CC=C5)C)=O)=C(O)C(O)=CC4=C3O)=C(C)C=C12)NC[C@@H](C6=CC=CC=C6)C
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Chemical Name[2,2'-Binaphthalene]-5,5'-dicarboxamide, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5,N5'-bis[(2R)-2-phenylpropyl]-,(1R)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wei J, et al. J Med Chem. 2010 May 27;53(10):4166-76.
2. Dash R, et al. Proc Natl Acad Sci U S A. 2011 May 24;108(21):8785-90.
3. Azab B, et al. J Cell Physiol. 2012 May;227(5):2145-53.
4. Goff DJ, et al. Cell Stem Cell. 2013 Mar 7;12(3):316-28.
2. Dash R, et al. Proc Natl Acad Sci U S A. 2011 May 24;108(21):8785-90.
3. Azab B, et al. J Cell Physiol. 2012 May;227(5):2145-53.
4. Goff DJ, et al. Cell Stem Cell. 2013 Mar 7;12(3):316-28.
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