BM-1197 ( BM1197 )

Catalog No. M11620 CAS No. 1391107-89-3

BM-1197 is a potent, specific dual inhibitor of Bcl-2 and Bcl-xL with Ki of <1 nM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

BM-1197
Note

Research use only, not for human use.
Brief Description

BM-1197 is a potent, specific dual inhibitor of Bcl-2 and Bcl-xL with Ki of <1 nM.
Description

BM-1197 is a potent, specific dual inhibitor of Bcl-2 and Bcl-xL with Ki of <1 nM, shows >1,000-fold selectivity over Mcl-1; exerts potent growth-inhibitory activity in 7 of 12 small cell lung cancer cell lines tested and induces mechanism-based apoptotic cell death, induces complete and long-lasting tumor regression in vivo.
Synonyms

BM1197
Pathway

Angiogenesis
Target

Bcl-2
Recptor

Bcl-2
Research Area

——
Indication

——

Chemical Information

CAS Number

1391107-89-3
Formula Weight

1131.77
Molecular Formula

C53H59ClF4N6O7S4
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

N-[4-[4-[3-[2-(4-Chlorophenyl)-5-methyl-1-(1-methylethyl)-4-(methylsulfonyl)-1H-pyrrol-3-yl]-5-fluorophenyl]-1-piperazinyl]phenyl]-4-[[(1R)-3-(4-hydroxy-1-piperidinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]benzenesulfonamide

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Bai L, et al. PLoS One. 2014 Jun 5;9(6):e99404.
2. Ye L, et al. Tumour Biol. 2015 May;36(5):3447-55.
3. Acasigua GA, et al. Oral Oncol. 2015 Sep;51(9):839-47.

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