SW-100 ( SW100;SW 100 )

Catalog No. M13382 CAS No. 2126744-35-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

SW-100
Note

Research use only, not for human use.
Brief Description

SW-100 (SW100) is a potent, selective, brain penetrable HDAC6 inhibitor with IC50 of 2.3 nM.
Description

SW-100 (SW100) is a potent, selective, brain penetrable HDAC6 inhibitor with IC50 of 2.3 nM, displays >1,000-fold selectivity over all other class I, II, and IV HDAC isoforms; selectively inhibits HDAC6-CD2 and enhances α-tubulin acetylation in cells with no effect on histone acetylation and selectively restores the impaired acetylated α-tubulin levels in the hippocampus of Fmr1-/- mice; ameliorates several memory and learning impairments in Fmr1-/- mice, thus modeling the intellectual deficiencies associated with Fragile X syndrome (FXS).
Synonyms

SW100;SW 100
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC
Research Area

——
Indication

——

CAS Number

2126744-35-0
Formula Weight

316.79
Molecular Formula

C17H17ClN2O2
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 125 mg/mL 394.60 mM
SMILES

C1CC2=C(C=CC(=C2)Cl)N(C1)CC3=CC=C(C=C3)C(=O)NO
Chemical Name

4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-N-hydroxybenzamide

1. Kozikowski A, et al. ACS Chem Neurosci. 2018 Dec 4. doi: 10.1021/acschemneuro.8b00600.

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