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SIS17

CAS No. 2374313-54-7

SIS17( —— )

Catalog No. M20333 CAS No. 2374313-54-7

SIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17 is active in cells and inhibited the demyristoylation of a known HDAC11 substrate serine hydroxymethyl transferase 2 without inhibiting other HDACs.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 88 In Stock
25MG 170 In Stock
50MG 290 In Stock
100MG 462 In Stock
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Biological Information

  • Product Name
    SIS17
  • Note
    Research use only, not for human use.
  • Brief Description
    SIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17 is active in cells and inhibited the demyristoylation of a known HDAC11 substrate serine hydroxymethyl transferase 2 without inhibiting other HDACs.
  • Description
    SIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17 is active in cells and inhibited the demyristoylation of a known HDAC11 substrate serine hydroxymethyl transferase 2 without inhibiting other HDACs.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC11
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2374313-54-7
  • Formula Weight
    366.6
  • Molecular Formula
    C21H38N2OS?
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL?(340.97 mM)
  • SMILES
    CCCCCCCCCCCCCCCCNNC(=O)c1cccs1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Son S I Cao J Zhu C L et al. Activity-Guided Design of HDAC11-Specific Inhibitors[J]. ACS Chemical Biology 2019 14(7):1393-1397.
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