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MPT0E028
CAS No. 1338320-94-7
MPT0E028 ( MPT0 E028 )
Catalog No. M11358 CAS No. 1338320-94-7
MPT0E028 (MPT 0E028) is a potent HDAC inhibitor that inhibits nuclear HDAC activity with IC50 of 11.1 nM in HeLa cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 194 | Get Quote |
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| 50MG | 896 | Get Quote |
|
| 100MG | 1566 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameMPT0E028
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NoteResearch use only, not for human use.
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Brief DescriptionMPT0E028 (MPT 0E028) is a potent HDAC inhibitor that inhibits nuclear HDAC activity with IC50 of 11.1 nM in HeLa cells.
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DescriptionMPT0E028 (MPT 0E028) is a potent HDAC inhibitor that inhibits nuclear HDAC activity with IC50 of 11.1 nM in HeLa cells, 9-30 times more potent than SAHA; inhibits class I HDAC1, HDAC2, and class Iib HDAC6 with IC50 of 53, 106, and 29.5 nM, respectively, weakly inhibits HDAC8 (IC50=2.5 uM), but not for HDAC4 (IC50>10 uM); inhibits the growth of HCT116 and MDA-MB-231 cells with IC50 of 0.09 and 0.19 uM; inhibits HCT116 tumor xenograft in vivo without significant adverse effects, shows stronger anti-cancer efficacy than SAHA.Solid Tumors Phase 1 Clinical
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SynonymsMPT0 E028
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC
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Research AreaCancer
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IndicationSolid Tumors
Chemical Information
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CAS Number1338320-94-7
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Formula Weight344.39
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Molecular FormulaC17H16N2O4S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NO)/C=C/C1=CC2=C(N(S(=O)(C3=CC=CC=C3)=O)CC2)C=C1
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Chemical Name(E)-N-hydroxy-3-(1-(phenylsulfonyl)indolin-5-yl)acrylamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Huang HL, et al. PLoS One. 2012;7(8):e43645.
2. Chen MC, et al. Cell Death Dis. 2013 Sep 19;4:e810.
3. Chen CH, et al. Clin Cancer Res. 2014 Mar 1;20(5):1274-1287.
4. Huang HL, et al. Oncotarget. 2015 Mar 10;6(7):4976-91.
2. Chen MC, et al. Cell Death Dis. 2013 Sep 19;4:e810.
3. Chen CH, et al. Clin Cancer Res. 2014 Mar 1;20(5):1274-1287.
4. Huang HL, et al. Oncotarget. 2015 Mar 10;6(7):4976-91.
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