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STF-31
CAS No. 724741-75-7
STF-31( STF31 | STF-31 | STF 31 )
Catalog No. M15774 CAS No. 724741-75-7
A selective GLUT1 inhibitor that does not bind to other glucose transporters.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 41 | In Stock |
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| 5MG | 67 | In Stock |
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| 10MG | 104 | In Stock |
|
| 25MG | 219 | In Stock |
|
| 50MG | 413 | In Stock |
|
| 100MG | 606 | In Stock |
|
| 500MG | 1278 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSTF-31
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NoteResearch use only, not for human use.
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Brief DescriptionA selective GLUT1 inhibitor that does not bind to other glucose transporters.
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DescriptionA selective GLUT1 inhibitor that does not bind to other glucose transporters; selectively kills RCCs by specifically targeting glucose uptake through GLUT1 and exploiting the unique dependence of these cells on GLUT1 for survival; also inhibits the enzymatic activity of NAMPT in a biochemical assay in vitro.
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In VitroCell Viability Assay Cell Line:Wild-type RCC4 cells (RCC4/VHL)and RCC4 cells without VHL Concentration:0.01, 0.1, 1, 10 μM Incubation Time:10 days Result:Reduced viability of RCC4 cells without VHL in a concentration-dependent manner when compared to their wild-type counterparts.
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In VivoAnimal Model:Twelve-week old C57BL/6J and CX3CR1gfp/+ miceDosage:10 mg/kg Administration:I.p. injections; twice daily for 2 days, followed by once daily for another 3 days Result:Improved photoreceptor survival and reduced microglial activation of CX3CR1gfp/+ mice, and not induced any C57BL/6J mice retinal cell death.
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SynonymsSTF31 | STF-31 | STF 31
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PathwayMembrane Transporter/Ion Channel
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TargetGLUT
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RecptorGLUT1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number724741-75-7
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Formula Weight423.5279
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Molecular FormulaC23H25N3O3S
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 34 mg/mL
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SMILESO=C(NC1=CC=CN=C1)C2=CC=C(CNS(=O)(C3=CC=C(C(C)(C)C)C=C3)=O)C=C2
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Chemical NameBenzamide, 4-[[[[4-(1,1-dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinyl-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chan DA, et al. Sci Transl Med. 2011 Aug 3;3(94):94ra70.
2. Adams DJ, et al. ACS Chem Biol. 2014 Oct 17;9(10):2247-54.
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