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BAY-876
CAS No. 1799753-84-6
BAY-876( BAY876 )
Catalog No. M12727 CAS No. 1799753-84-6
A potent, highly selective and oral bioavailable GLUT1 inhibitor with IC50 of 2 nM; displays >100-fold selectivity against GLUT2, GLUT3, and GLUT4.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 71 | In Stock |
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| 5MG | 87 | In Stock |
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| 10MG | 133 | In Stock |
|
| 25MG | 246 | In Stock |
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| 50MG | 404 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBAY-876
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, highly selective and oral bioavailable GLUT1 inhibitor with IC50 of 2 nM; displays >100-fold selectivity against GLUT2, GLUT3, and GLUT4.
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DescriptionA potent, highly selective and oral bioavailable GLUT1 inhibitor with IC50 of 2 nM; displays >100-fold selectivity against GLUT2, GLUT3, and GLUT4; exhibits good metabolic stability in?vitro and high oral bioavailability in?vivo.
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In VitroCell Proliferation Assay Cell Line:SKOV-3 and OVCAR-3 cells Concentration:25, 50, 75 nM Incubation Time: 24 and 72 hours Result:Led to a dose-dependent decrease in numbers of SKOV-3 and OVCAR-3 cells.
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In VivoAnimal Model:Female NOD-scid IL2rgnull (NSG) mice carrying SKOV-3 subcutaneous (s.c.) xenograftsDosage: 1.5, 3, 4.5 mg/kg Administration:Oral administration; daily; for 28 days Result:Caused a clear dose-dependent inhibition of tumorigenicity.
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SynonymsBAY876
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PathwayMembrane Transporter/Ion Channel
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TargetGLUT
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RecptorGLUT1|GLUT2|GLUT3|GLUT4
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1799753-84-6
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Formula Weight496.4164
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Molecular FormulaC24H16F4N6O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 100 mg/mL
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SMILESO=C(C1=NC2=CC(F)=CC=C2C(C(NC3=C(C)N(CC4=CC=C(C=C4)C#N)N=C3C(F)(F)F)=O)=C1)N
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Chemical Name2,4-Quinolinedicarboxamide, N4-[1-[(4-cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Siebeneicher H, et al. ChemMedChem. 2016 Oct 19;11(20):2261-2271.
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