MM-206

CAS No. 1809581-87-0

MM-206( MM206 | MM 206 )

Catalog No. M12775 CAS No. 1809581-87-0

A novel small molecule STAT3 inhibitor that inhibits STAT3 DNA binding activity with IC50 of 1.16 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MM-206
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel small molecule STAT3 inhibitor that inhibits STAT3 DNA binding activity with IC50 of 1.16 uM.
  • Description
    A novel small molecule STAT3 inhibitor that inhibits STAT3 DNA binding activity with IC50 of 1.16 uM, binds to the STAT3 coiled-coil domain (CCD); also inhibits G-CSF-induced STAT3 phosphorylation in AML cell lines with IC50 of 0.8-1.9 uM,
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    MM206 | MM 206
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1809581-87-0
  • Formula Weight
    497.454
  • Molecular Formula
    C22H12F5NO3S2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=S(C1=C(F)C(F)=C(F)C(F)=C1F)(NC2=C3C=CC=CC3=C(O)C(SC4=CC=CC=C4)=C2)=O
  • Chemical Name
    2,3,4,5,6-pentafluoro-N-(4-hydroxy-3-(phenylthio)naphthalen-1-yl)benzenesulfonamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Minus MB, et al. Angew Chem Int Ed Engl. 2015 Oct 26;54(44):13085-9.
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