ST-168 ( ST168 )

Catalog No. M13380 CAS No. 2126038-25-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ST-168
Note

Research use only, not for human use.
Brief Description

ST-168 is a novel potent, orally available MEK/PI3K bifunctional inhibitor.
Description

ST-168 is a novel potent, orally available MEK/PI3K bifunctional inhibitor with IC50 of 182, 69.2, 1482, 2293, and 41.7 nM for MEK1, PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively; exhibits improved inhibition toward PI3K isoforms compared to ST-162; demonstrates superior tumoricidal efficacy over ST-162 in an A375 melanoma spheroid tumor model.
Synonyms

ST168
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

PI3K
Research Area

——
Indication

——

CAS Number

2126038-25-1
Formula Weight

1010.76
Molecular Formula

C41H44F5IN10O7
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

N-(2-(2-(2-(3-(4-(4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)piperazin-1-yl)-3-oxopropoxy)ethoxy)ethoxy)ethoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide

1. Van Dort ME, et al. ACS Med Chem Lett. 2017 Jul 24;8(8):808-813.

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